| 赛庚啶对心、脑、肾血流量的影响及对实验性脑血栓的影响 |
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| 引用本文： | 鞠敏,王美纳,刘俊田,康爱群. 赛庚啶对心、脑、肾血流量的影响及对实验性脑血栓的影响[J]. 中国药理学通报, 1997, 0(5) |
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| 作者姓名： | 鞠敏 王美纳 刘俊田 康爱群 |
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| 作者单位： | 西安医科大学药理教研室!西安，710061，西安医科大学药理教研室!西安，710061，西安医科大学药理教研室!西安，710061，西安医科大学药理教研室!西安，710061 |
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| 摘 要： | 目的观察赛庚啶对大鼠脑血流量、心肌血流量及肾血流量的影响及其对以ADP、凝血酶、肾上腺素复合物为诱导剂的实验性脑血栓的影响。方法：放射性微球法。结果：赛庚啶iv2mg·kg(－1)可以使正常SD大鼠脑血流量增加28．6％，心肌血流量增加43．0％，肾皮质血流量增加45．6％，与对照组相比差异有显著性。ivlmg·kg(－1)可以抑制实验性脑血栓的形成。结论：赛庚啶可以改善心、脑、肾的血液循环。
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| 关 键 词： | 赛庚啶 放射性微球 脑血流量 心肌血流量 肾血流量 脑血栓 |
Influence of cyproheptadine on cerebral myocardial and renal blood flow and effects of cyproheptadine on experimental cerebral thrombosis in rats |
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| JU Min, WANG Mei-Na, LIU Jun-Tian, KANG Ai-Qun. Influence of cyproheptadine on cerebral myocardial and renal blood flow and effects of cyproheptadine on experimental cerebral thrombosis in rats[J]. Chinese Pharmacological Bulletin, 1997, 0(5) |
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| Authors: | JU Min WANG Mei-Na LIU Jun-Tian KANG Ai-Qun |
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| Abstract: | To study the influence ofcyproheptadine on the cerebral blood flow(CBF), myocardial blood flow (MBF) and renalblood flow (RBF) of rats. METHODS: Withchromium radioisotopes (5lCr ) using the radioac-tive biomicrosphere assay labeling frog erythro-cytes. RESULTS: Cyp iv 2 mg. kg -1 increasedCBF by 28. 6%. MBF by 43. 0%, RBF by45. 6%. Cyp iv I mg. kg-1 inhibited experimental cerebral thrombosis induced by a co-thrombus inducer, a mixture of ADP. thrombin andepinephrine. CONCLUSIONS: The results suggested that Cyp may be beneficial to cerebralmyocardial and renal circulation. |
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| Keywords: | cyproheptadine radioactive biomicrosphere cerebral blood flow myocardial blood flow renal blood flow cerebral thrombosis |
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