| 干扰素诱导抗病毒蛋白基因多态性与肝炎疗效的相关性 |
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| 引用本文： | 邹梦娜,陈新月. 干扰素诱导抗病毒蛋白基因多态性与肝炎疗效的相关性[J]. 国际流行病学传染病学杂志, 2007, 34(1) |
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| 作者姓名： | 邹梦娜 陈新月 |
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| 作者单位： | 100069,北京,首都医科大学附属佑安医院特需病房;100069,北京,首都医科大学附属佑安医院特需病房 |
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| 基金项目： | 2005年首都医学发展科研项目(20053057) |
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| 摘 要： | IFN治疗是慢性病毒性肝炎病因治疗的主要手段,但是相同的治疗方法在不同的患者中,疗效差异很大,可能与不同个体的免疫遗传差异有关,即不同个体IFN诱导的抗病毒蛋白的基因多态性不同,进而影响了慢性肝炎疗效。现就IFN诱导抗病毒蛋白的基因多态性与慢性肝炎抗病毒疗效的相关性进行综述。
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| 关 键 词： | 慢性肝炎 干扰素 基因多态性 |
Genetic polymorphisms in interferon induced antiviral proteins and response to interferon treatment in hepatitis |
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| ZOU Meng-na,CHEN Xin-yue. Genetic polymorphisms in interferon induced antiviral proteins and response to interferon treatment in hepatitis[J]. International Journal of Epidemiology and Infectious Disease, 2007, 34(1) |
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| Authors: | ZOU Meng-na CHEN Xin-yue |
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| Abstract: | Interferon therapy remains a main etiological treatment in chronic viral hepatitis.However,the therapeutic effect displays great distinction in different patients with identical treatment,which may relate to immune genetic diversity among individuals.The distinct genetic polymorphisms of IFN induced antiviral proteins from different individuals influence the therapeutic effect of chronic hepatitis.This article reviews the genetic polymorphisms in interferon induced antiviral proteins associated with antiviral therapy in chronic hepatitis. |
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| Keywords: | Chronic hepatitis Interferon Genetic polymorphism |
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