|
|||||
|
|
Electroacupuncture diminishes P2X2 and P2X3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity |
|
| Authors: | Zhijun Weng Luyi Wu Yuan Lu Lidong Wang Linying Tan Ming Dong Yuhu Xin |
| Institution: | Zhijun Weng (Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China)；Luyi Wu (Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China)；Yuan Lu (Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China)；Lidong Wang (Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China)；Linying Tan (Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China)；Ming Dong (Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China)；Yuhu Xin (Fudan University Shanghai Cancer Center, Shanghai 200032, China)； |
| Abstract: | Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X2 and P2X3 receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X2 and P2X3 receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X2 and P2X3 receptor expression in dorsal root ganglia. |
| Keywords: | neural regeneration acupuncture and moxibustion P2X2 P2X3 visceral hypersensitivity irritable bowel syndrome electroacupuncture P2 purinergic receptors abdominal withdrawal reflex scores acupuncture and moxibustion peripheral nerve injury grants-supported paper photographs-containing paper neuroregeneration |
| 本文献已被 CNKI 等数据库收录！ | |