Electroacupuncture regulates glucose-inhibited neurons in treatment of simple obesity |
| |
Authors: | Zhi Yu Youbing Xia Chuanhui Ju Qinghua Shao Zhen Mao Yun Gu Bin Xu |
| |
Affiliation: | Zhi Yu (Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine,Nanjing 210029, Jiangsu Province, China);Youbing Xia (Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine,Nanjing 210029, Jiangsu Province, China);Chuanhui Ju (Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine,Nanjing 210029, Jiangsu Province, China);Qinghua Shao (Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine,Nanjing 210029, Jiangsu Province, China);Zhen Mao (Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine,Nanjing 210029, Jiangsu Province, China);Yun Gu (Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine,Nanjing 210029, Jiangsu Province, China);Bin Xu (Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Ministry of Education of China, Nanjing University of Chinese Medicine,Nanjing 210029, Jiangsu Province, China); |
| |
Abstract: | The glucose-inhibited neurons present in the lateral hypothalamic area are regarded as glucose detectors. This structure is involved in the regulation of food intake through extracellular blood glucose concentrations, and plays a crucial role in obesity onset. In the present study, obesity models established with high fat feeding were treated with electroacupuncture at Zusanli (ST36)/Inner Court (ST44) on the left side and Tianshu (ST25) bilaterally. We found that electroacupuncture could effectively reduce body weight and the fat-weight ratio, and decrease serum leptin, resistin, tumor necrosis factor alpha, and neuropeptide Y levels, while increase serum adiponectin and cholecystokinin-8 levels. This treatment altered the electrical activity of glucose-inhibited neurons in the lateral hypothalamic area, with electroacupuncture at Zusanli/Inner Court exerting an inhibitory effect, while electroacupuncture at bilateral Tianshu exerting an excitatory effect. These data suggest that electroacupuncture at the lower limbs and abdominal cavity is an effective means for regulating the activity of glucose-inhibited neurons in the lateral hypothalamic area and for improving the secretory function of adipose tissue. |
| |
Keywords: | neural regeneration acupuncture and moxibustion electroacupuncture acupoint adipose tissue hypothalamus obesity feeding center acupuncture regeneration grants-supported paper neuroregeneration |
本文献已被 CNKI 等数据库收录! |
|