联合检测CA125、CYFRA21-1、NSE和CEA对肺癌诊断价值的探讨

目的 探讨糖类抗原125（CA125）、细胞角蛋白21-1（CYFRA21-1）、神经元特异性烯醇化酶（NSE）、癌胚抗原（CEA）联合检测对肺癌的诊断价值.方法 应用检测灵敏度高和线性范围宽的电化学发光技术对68例肺癌、41例肺良性疾病及33例健康体检者血清进行检测.结果 肺癌组血清CA125、CYFRA21-1、NSE和CEA含量均显著高于健康对照组和肺良性疾病组（P〈0.01）.单项肿瘤指标对肺癌检测敏感性分别为73.5%、75.0%、79.4%、82.4%,联合检测可提高检测敏感性达97.1%;如以任何三项以上阳性作为肺癌的诊断依据,则敏感性为75.0%,而对照组无1例阳性.结论 CA125、CYFRA21-1、NSE和CEA联合检测可显著提高肺癌诊断的敏感性,在肺癌的早期诊断方面可为临床提供有价值的资料.

Diagnostic value of combined detection of CA125,CYFRA21-1,NSE and CEA in lung carcinoma

Objective To study diagnostic value of simultaneous detection of four tumor markers （ CA125, CYFRA21 - 1, NSE,CEA） in patients with lung cancer. Methods These tumor markers in serum were measured with electrochemiluminescence intmunoassay in 68 patients with lung cancer,41 benign lung disease and 33 healthy subjects. Results The levels of the markers in lung cancer group were all higher than those of benign lung diseases and healthy subjects （P 〈 0. 01 ）. The sensitivity of single tumor marker （ CA125 ,CYFRA21 - 1 ,NSE,CEA）was 73.5% ,75.0% ,79. 4% ,82.4% respectively. The sensitivity of combined measurement was 97.1%. By three positive indexes in three tumor markers as diagnostic base on lung cancer, the positive rate was 75.0%, but no positive case was found in benign lung diseases group and control group. Conclusion Combined measurement of various serum tumor markers can significantly increase the diagnostic sensitivity for long cancer, and provide useful information for early diagnosis of disease in patients with lung cancer.