白藜芦醇对荷瘤大鼠放疗后免疫功能的保护作用

目的探讨白藜芦醇对荷瘤大鼠放疗后免疫功能的保护作用。方法将30只荷瘤大鼠随机分成3组：A组为对照组，给予生理盐水灌胃；B组给予γ射线局部照射及生理盐水灌胃；C组给予γ射线局部照射及白藜芦醇灌胃；末次照射3d后观察血常规、胸腺指数、脾脏指数、瘤重及抑瘤牢、超氧化物歧化酶（SOD）活性、丙二醛（MDA）含量、T淋巴细胞亚群百分比。结果与A组相比，B组的血细胞数、胸腺指数和脾脏指数、T淋巴细胞亚群百分比、SOD活性降低（P〈0．05），MDA含量升高（P〈0．05）；与B组相比，C组的血细胞数、胸腺指数和脾脏指数、T淋巴细胞弧群百分比、SOD活性升高（P〈0．05），MDA含量降低（P〈0．05）。结论自藜芦醇对荷瘤大鼠放疗后免疫功能具有保护作用

The protective effect of resveratrol on the immune function in tumor - bearing rats with radiotherapy

Objective To investigate the protective effect of resveratrol on the immune function in tumor - bearing rats with radiotherapy. Methods Thirty tumor - bearing rats were randomly divided into 3 groups： A group （Control group, intragastric administration with normal saline） ; B group （ γ ray local irradiation and intragastric administration with normal saline） ; C group （γ ray local irradiation and intragastric administration with resveratrol ）. On 3rd day after irradiation, blood routine, thymus index and spleen index, tumor weight and tumor - inhibition rate, SOD activity, MDA level, as well as percentage of T cell subsets were observed. Results Comnparod with A group, in B group, the numbers of blood cell, thymus index and spleen index, percentage of T cell subset, as well as SOD activity were decreased（ P 〈 0. 05） ; however, the level of MDA was increased（ P 〈0.05 ）. Compared with B group, in C group, the numbers of blood cell, thymus index and spleen index, percentage of T cell subset, as well as SOD activity were increased （P 〈0.05 ） ; however, the level of MDA was decreased （ P 〈 0. 05）. Conclusion Resveratrol has a protective effect on the immune function in tumor - bearing rats with radiotherapy.