艾司西酞普兰与氟西汀治疗老年抑郁的对照研究

目的 评价草酸艾司西酞普兰与氟西汀治疗老年抑郁症的临床疗效及安全性.方法 将62例老年抑郁症患者随机分为艾司西酞普兰组31例,氟西汀组31例,观察6周.于治疗前和治疗1周、2周、4周、6周末采取汉密尔顿抑郁量表评定疗效,不良反应量表评定不良反映.结果 艾司西酞普兰组显效率77.4%,氟西汀组77.2%,两组比较差异无统计学意义（P＞0.05） 艾司西酞普兰组不良反应发生率35.48%,氟西汀组51.62%,两组比较差异没有统计学意义（P＞0.05）.结论 艾司西酞普兰与氟西汀治疗老年抑郁症疗效相当,但艾司西酞普兰起效比氟西汀起效更快更安全,适合作为老年抑郁患者的一线用药.

Eseitalopram and Fluoxetine in the treatment of geriatric depression

Objective To investigate the efficacy and side effect of Escitalopram in the treatment of geriatric depression compared to Fluoxetine. Methods 62 case met the CCMD - 3 criteria for depression were divided into two groups randomly, treated with Escitalopram and Fluoxetine respectively for 6 weeks. The Hamilton Depression Rating Scale for Depression （HRSD） and Treatment Emergent Symptom Scale （TESS） were used to assess the therapeutic effect and side effect respectively. Results The effective power of Escitalopram group and Fluoxetine group are 77.4% and 77.2% respectively. The incidence of side effect of Escitalopram group and Fluoxetine group are 35.48% and 51.62% respectively. There was no significant difference between two groups in improvement rate and side effect （ P 〉 0. 05 ）. Conclusion Eseitalopram is as effective as Fluoxetine for the treatment of geriatric depression, and has fewer side effect and fast onset than Fluoxetine. Escitalopram have significant treatment effective, good tolerance and worth popularized on clinical conduct for the medical treatment on geriatric depression.