肾上腺素、血管加压素、纳洛酮联合应用对心肺复苏的疗效观察

目的:观察心肺复苏(CPR)时联合应用肾上腺素、血管加压素、纳洛酮的疗效,并探讨其可能的作用机制。方法:64例心跳、呼吸骤停患者随机分为3组:对照组(肾上腺素组)、治疗Ⅰ组(肾上腺素+血管加压素组)、治疗Ⅱ组(肾上腺素+血管加压素+纳洛酮组)。分别观察比较各组的自主循环、呼吸恢复时间,自主循环、呼吸恢复率及24h存活率、出院存活率。结果:与对照组比较,治疗Ⅰ、Ⅱ组的自主循环、呼吸恢复率,24h存活率、出院存活率均明显提高(P<0.01或P<0.05);自主循环、呼吸恢复时间均明显缩短(P<0.01)。结论:CPR时联合应用肾上腺素、血管加压素、纳洛酮能显著提高自主循环、呼吸恢复率,24h存活率、出院存活率;缩短自主循环、呼吸恢复时间,有效提高CPR的救治成功率。

Clinical Efficacy on Epinephrine and Vasopressin Combined with Naloxone in the Treatment of Cardiopulmonary Resuscitation

OBJECTIVE：To observe clinical efficacy of epinephrine combined with vasopressin and naloxone for cardiopulmonary resuscitation（CPR）and to investigate its mechanism. METHODS：64 patients with sudden cardiac and respiratory arrest were randomly divided into control group（epinephrine group）,treatment group Ⅰ（epinephrine＋vasopressin group）and treatment group Ⅱ（vasopressin＋epinephrine＋naloxone group）. Spontaneous circulation,breathing recovery time,restoration of spontaneous circulation and respiration rate,24 h survival rate and discharge survival rate were observed and compared among different groups. RESULTS：As compared with control group,spontaneous circulation,breathing recovery time 24 h survival rate and discharge survival rate in treatment group Ⅰ and Ⅱwere increased significantly（P0.01 or P0.05）. The duration of spontaneous circulation and breathing recovery time were shortened predominantly（P0.01）. CONCLUSION：The combination of epinephrine,vasopressin and naloxone in the CPR can significantly increase the recovery rate of spontaneous circulation and respiration,24 h survival rate and discharge survival rate and decrease duration of spontaneous circulation and breathing recovery time. The regime is good approach for CPR.