| 转铁蛋白在蛋白多肽药物口服给药中的应用 |
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| 引用本文： | 谢向阳,张建维,迟强,梅兴国. 转铁蛋白在蛋白多肽药物口服给药中的应用[J]. 国际药学研究杂志, 2008, 35(2): 133-135 |
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| 作者姓名： | 谢向阳 张建维 迟强 梅兴国 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850;河北医科大学药学院,河北石家庄,050017 |
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| 摘 要： | 转铁蛋白作为一种药物载体，在蛋白多肽药物的口服给药领域有着美好前景。以转铁蛋白作为药物载体，可以使蛋白肽类药物在肠道吸收；对转铁蛋白进行适当的修饰，可以提高其递送效率。本文概述了近年来转铁蛋白在蛋白多肽药物口服给药中的作用及有关转运机制的研究进展。
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| 关 键 词： | 转铁蛋白 投药 口服 蛋白 肽类 药物载体 药物释放系统 |
| 收稿时间： | 2007-10-19 |
Transferrin in peroral delivery of protein and peptide |
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| XIE Xiang-yang,ZHANG Jian-wei,CHI Qiang,MEI Xing-guo. Transferrin in peroral delivery of protein and peptide[J]. Foreign Medical Sciences(Section of Pharmarcy), 2008, 35(2): 133-135 |
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| Authors: | XIE Xiang-yang ZHANG Jian-wei CHI Qiang MEI Xing-guo |
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| Affiliation: | XIE Xiang-yang1, ZHANG Jian-wei2, CHI Qiang1, MEI Xing-guo1 |
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| Abstract: | The utilization of transferrin as a carrier in peptide and protein peroral drug delivery is a promising approach. Using transferrin as a drug carrier can render the absorption of peptide and protein in gastrointestinal tract. Modified transferrin will increase its drug delivery efficiency. In this paper, the progress of transferrin applied in protein and peptide peroral delivery is reviewed， and the transportation mechanism of transferrin is also discussed. |
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| Keywords: | transferrin administration oral protein peptides drug carrier drug delivery systems |
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