| CD4+CD25+Tr细胞趋化性细胞因子受体表达的生物学意义研究 |
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| 引用本文： | 杨巍,于春雷. CD4+CD25+Tr细胞趋化性细胞因子受体表达的生物学意义研究[J]. 国际免疫学杂志, 2006, 29(6): 376-380 |
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| 作者姓名： | 杨巍 于春雷 |
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| 作者单位： | 130021,长春,吉林大学基础医学院免疫学教研室;130021,长春,吉林大学基础医学院免疫学教研室 |
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| 摘 要： | CD4 CD25 调节性T(Tr)细胞在维持外周自身耐受从而防止自身免疫病的发生、抑制严重的炎症性疾病和下调肿瘤免疫应答中发挥着重要的作用。然而关于它们的免疫抑制机制的分子基础和迁移特性仍不明确。对CD4 CD25 Tr细胞上趋化性细胞因子受体表达的研究将有助于我们更好地了解这群细胞的作用机制。了解CD4 CD25 Tr细胞、趋化性细胞因子、趋化性细胞因子受体和表达于CD4 CD25 Tr细胞上的趋化性细胞因子受体以及它们与不同的抗原提呈细胞(APCs)之间的作用的最新研究进展十分必要。
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| 关 键 词： | CD4+CD25+调节性T细胞 趋化性细胞因子 趋化性细胞因子受体 APCs |
| 文章编号： | 1673-4394(2006)06-0376-04 |
| 收稿时间： | 2005-12-12 |
| 修稿时间： | 2005-12-12 |
The Study of Chemokine Receptors Expressing on CD4+ CD25+ Tr Cells |
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| YANG Wei,YU Chun-lei. The Study of Chemokine Receptors Expressing on CD4+ CD25+ Tr Cells[J]. International Journal of Immunology, 2006, 29(6): 376-380 |
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| Authors: | YANG Wei YU Chun-lei |
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| Affiliation: | Department of Immunology, Basic School of Medical Sciences, Jilin University, Changchun 130021, China |
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| Abstract: | CD4 CD25 regulatory T (Tr) cells play a critical role in the maintenance of self-tolerance, preventing autoimmune disease, inhibiting harmful infectious diseases and down-regulating anti-tumour immune response. However, the molecular basis of immunosuppressive and the trafficking properties of these cells are unknown. Studying the chemokine receptors expressing on CD4 CD25 Tr cells will help us to understand the mechanism of this subset more clearly. This review focuses on recent advances in understanding the CD4 CD25 regulatory T cells, chemokine and receptor, chemokine receptor expressing on CD4 CD25 Tr cells and the attraction of these cells by antigen presenting cells (APCs). |
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| Keywords: | CD4 CD25 Tr cells Chemokine Chemokine receptor APCs |
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