| 尿激酶、前列腺素E_1联合溶栓对家兔全身纤溶系统的影响 |
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| 引用本文： | 贺抗,阎纪英,李保. 尿激酶、前列腺素E_1联合溶栓对家兔全身纤溶系统的影响[J]. 中国循环杂志, 1994, 0(1) |
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| 作者姓名： | 贺抗 阎纪英 李保 |
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| 作者单位： | 山西医学院第一附属医院，山西省心血管研究所 |
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| 摘 要： | 在家兔髂股动脉血栓模型观察尿激酶（ＵＫ）和前列腺素Ｅ１（ＰＧＥ１）联合溶栓的效果。结果如下：①经导管动脉联合用药（简称联用），优于单用ＵＫ，再通率为１００％。优于常规静脉途径（再通率５０％）；②静脉联用组全身纤溶激活，即总纤溶活力增强，纤溶酶原（ＰＬＧ）和纤维蛋白降解产物（ＦＤＰ）增高。有出血的潜在危险，而动脉联用组全身纤溶改变小于静脉联用及动脉单药（ＵＫ）组。经导管动脉内联合用ＵＫ和ＰＧＥ１是一种疗效高、副作用小的溶栓方法。
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| 关 键 词： | 动脉内给药，尿激酶，前列腺素E_1，溶栓 |
THE EFFECT OF THROMBOLYSIS BY COMBINED USE OF UROKINASE AND PROSTAGLANDIN E_1 ON SYSTEMIC FIBRINOLYSIS IN RABBITS |
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| He Kang, Yan Ji-Ying, Li Bao.. THE EFFECT OF THROMBOLYSIS BY COMBINED USE OF UROKINASE AND PROSTAGLANDIN E_1 ON SYSTEMIC FIBRINOLYSIS IN RABBITS[J]. Chinese Circulation Journal, 1994, 0(1) |
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| Authors: | He Kang Yan Ji-Ying Li Bao. |
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| Abstract: | In this study, we compared the thrombolytic efficacy of urokinase (UK) alone or combined with prostaglandin E1 (PGE1) in rabbit thrombosis model and investigated the systemic fibrinolytic response.The results showed that PGE1 can enhance the thrombolytic effect of UK and the effective dose of UK was reduced by 50%. Consequently, systemic activation of the fibrinolytic system was alleviated. Intra-arterial infusion of UK plus PGE1 is superior to UK alone and transcatheter intra-arterial infusion of UK and PGE1 is superior to the intravenous approach. Intravenous UK plus PGE1 caused abnormality of the systemic fibrinolysis. |
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| Keywords: | Intra-arterial Urokinase Prostagl andin E_1 Fibrinolysis Thrombolysis |
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