| Endogenous Ouabain in Hypertensive Disorder Complicating Pregnancy |
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| 引用本文： | 吴黎,熊承良,苏萍. Endogenous Ouabain in Hypertensive Disorder Complicating Pregnancy[J]. 华中科技大学学报(医学英德文版), 2007, 27(6): 717-720. DOI: 10.1007/s11596-007-0626-8 |
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| 作者姓名： | 吴黎 熊承良 苏萍 |
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| 作者单位： | Family Planning Research Institute Tongji Medical College Huazhong University of Science and Technology，Family Planning Research Institute Tongji Medical College Huazhong University of Science and Technology，Family Planning Research Institute Tongji Medical College Huazhong University of Science and Technology，Wuhan 430030 China，Wuhan 430030 China，Wuhan 430030 China |
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| 基金项目： | 教育部留学回国人员科研启动基金 |
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| 摘 要： | Expression of endogenous ouabain in placenta and the concentrations of serum ET-1 and NO were examined in 30 patients with hypertensive disorder complicating pregnancy (HDCP) and 30 healthy pregnant women to investigate the effect of endogenous ouabain on HDCP. Compared with the healthy pregnant group, the expression of endogenous ouabain dramatically increased in the HDCP groups (P<0.01). There was a significantly positive correlation between the expression of en- dogenous ouabain with ET-1 (r= 0.5567, P<0.01), while the correlation of endogenous ouabain and NO was significantly negative (r=-0.6895, P<0.01). As expected, the correlation between ET-1 and NO was negative (r=-0.7796, P<0.01). ET-1 concentrations of maternal and cord sera in HDCP groups were significantly higher in comparison with healthy pregnant group (P<0.01). On the con- trast, NO concentrations were much lower in the maternal and cord sera of HDCP groups as com- pared with healthy pregnant group (P<0.01). Our data suggest that endogenous ouabain is directly involved in the nosogenesis of HDCP, with accompanying decreased NO and the elevated of ET-1.
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| 关 键 词： | 内源性乌本苷 高血压 妊娠 并发症 |
| 收稿时间： | 2007-10-19 |
Endogenous ouabain in hypertensive disorder complicating pregnancy |
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| Wu Li,Xiong Chengliang,Su Ping. Endogenous ouabain in hypertensive disorder complicating pregnancy[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2007, 27(6): 717-720. DOI: 10.1007/s11596-007-0626-8 |
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| Authors: | Wu Li Xiong Chengliang Su Ping |
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| Affiliation: | Family Planning Research Institute, Tonal Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Expression of endogenous ouabain in placenta and the concentrations of serum ET-1 and NO were examined in 30 patients with hypertensive disorder complicating pregnancy (HDCP) and 30 healthy pregnant women to investigate the effect of endogenous ouabain on HDCP. Compared with the healthy pregnant group, the expression of endogenous ouabain dramatically increased in the HDCP groups (P<0.01). There was a significantly positive correlation between the expression of en- dogenous ouabain with ET-1 (r= 0.5567, P<0.01), while the correlation of endogenous ouabain and NO was significantly negative (r=-0.6895, P<0.01). As expected, the correlation between ET-1 and NO was negative (r=-0.7796, P<0.01). ET-1 concentrations of maternal and cord sera in HDCP groups were significantly higher in comparison with healthy pregnant group (P<0.01). On the con- trast, NO concentrations were much lower in the maternal and cord sera of HDCP groups as com- pared with healthy pregnant group (P<0.01). Our data suggest that endogenous ouabain is directly involved in the nosogenesis of HDCP, with accompanying decreased NO and the elevated of ET-1. |
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| Keywords: | endogenous ouabain hypertensive disorder complicating pregnancy nitrogen mon-oxidum endothelin-1 |
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