Malignant giant cell tumor of bone |
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Authors: | Tomas Aparisi Bengt Arborgh Jan L E Ericsson |
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Institution: | (1) Department of Orthopedic Surgery at Karolinska Hospital, Karolinska Institute Medical School, Stockholm;(2) The Department of Pathology at Huddinge Hospital, Karolinska Institute Medical School, Stockholm;(3) The Central Laboratory of Clinical Pathology at University Hospital, University of Uppsala, Sweden |
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Abstract: | Summary The fine structure of the different cell types constituting a primary malignant giant cell tumor of bone has been studied and the localization of acid phosphatase in relation to the subcellular organelles been demonstrated. Three distinct cell types with characteristic ultrastructural features were observed: giant cells, fibroblast-like cells, and cells with abundant lipid inclusions and mitochondria. Certain differences were noted between these three cell types and their counterparts in benign giant cell tumors of bone (described in a separate report). The enzyme histochemical and morphological data suggested that the giant cells in the malignant tumor might possess a more active and expansive lysosomal apparatus than corresponding cells in the benign variant.This investigation has been aided by a grant from the Swedish Cancer Society (grant 77:64, project No. 617-B77-06XA) |
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Keywords: | Giant cell tumor Ultrastructure Acid phosphatase Lysosomes Bone tumors |
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