阿苯达唑严重不良反应

目的 了解阿苯达唑引起的严重不良反应.并提出意见与建议.方法 检索了<中国期刊全文数据库>(1994～2004)有关文献共40篇,病例110例.结果 服用阿苯达唑的患者中出现了严重的不良反应,主要为脑炎综合征(41.8%),其次为变态反应性休克(16.4%)、流感样综合征(7.3%)、过敏性紫癜(6.4%)、药疹(6.4%)、急性肝损伤(5.5%).其他少见的不良反应为脱发、血尿、胃出血、过敏性肠炎、视神经炎、心脏传导障碍、癫痫发作、高热和左下肢抽搐.结论 对阿苯达唑引起的严重不良反应,广大用药人群和临床医生必须高度重视,并继续加强对阿苯达唑不良反应的监测.

Serious adverse reactions associated with Albendazole

Objective Understand the serious adverse reactions associated with albendazole and make the suggestion to avoid them. Method Searching Chinese Journal Full-text Database from 1994 to 2004 and getting 40 literatures and 100 cases associated with albendazole. Results Serious ADR appeared in the patients taking albendazole. Encephalitis syndrome was the most common (41.8%), then allergic shock(16.4%), influenza-like syndrom(7.3%), allergic purpura(6.4%), drug rash(6.4%), acute hepatic injury(5.5%). Other rare ADR include alopecia, hematuria, gastrorrhagia, hypersensitive enteritis, optic neuritis, heart block, epilepsy seizure, hyperpyrexia and left lower extremity tic. Conclusion People and physicians should pay attention to ADR associated with albendazole and the ADRs should be monitored continually.