| 丹参多酚酸盐对ApoE-/-小鼠血清IL-6的影响 |
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| 引用本文： | 高玉琪,罗南萍,梁春,吴宗贵. 丹参多酚酸盐对ApoE-/-小鼠血清IL-6的影响[J]. 放射免疫学杂志, 2011, 24(1): 15-17 |
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| 作者姓名： | 高玉琪 罗南萍 梁春 吴宗贵 |
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| 作者单位： | 高玉琪(济南军区总医院心内科,250031);罗南萍(济南军区总医院实验诊断科,250031);梁春,吴宗贵(第二军医大学长征医院心内科,200003) |
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| 摘 要： | 摘要目的：观察中药丹参多酚酸盐（salvianolate）对C57BIM6J ApoE-/-小鼠血清白细胞介素_6（Interleu—kin-6，IL-6）的影响，以探讨其抗动脉粥样硬化的可能机制。方法：给4周龄雄性C57BIM6J ApoE-/-小鼠喂食高脂饮食，腹腔注射丹参多酚酸盐，随机将其分为模型组（仅腹腔注射生理盐水）、丹参多酚酸盐低剂量（60mg／kg）组、中剂量（120mg／kg）组、高剂量（240mg／kg）组，每组6只，共24只；正常对照组（即C57BIM6J野生型小鼠）5只。24周末时处死各组小鼠，留取血清，采用特异性放射免疫分析各组小鼠血清IL-6水平。结果：24周末，随丹参多酚酸盐剂量的增加，ApoE-/-小鼠血清浓度逐渐降低，丹参多酚酸盐各浓度组血清IL-6水平均明显低于模型组（P均〈0．05）；丹参多酚酸盐120mg／kg组血清IL-6水平明显低于60mg／kg组（P〈0．05）；丹参多酚酸盐240mg／kg组血清IL-6水平明显低于120mg／kg组和60mg／kg组（P〈0．05），丹参多酚酸盐240mg／kg组IL-6浓度仍明显高于正常对照组水平。结论：丹参多酚酸盐各剂量组均能够降低ApoE-/-小鼠血清IL-6水平，随剂量增加，减低越明显，说明丹参多酚酸盐能够抑制动脉粥样硬化炎症反应，可能是其抗动脉粥样硬化的作用机制之一。
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| 关 键 词： | 丹参多酚酸盐白细胞介素-6 ApoE-/-小鼠放射免疫分析 |
Effect of Salvianolate on Serum Levels of Interleukin-6 in ApoE~(-/-) Mice Models of Atherosclerosis |
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| Gao Yu-qi,Luo Nan-ping,Liang Chun,et al.. Effect of Salvianolate on Serum Levels of Interleukin-6 in ApoE~(-/-) Mice Models of Atherosclerosis[J]. Journal of Radioimmanology, 2011, 24(1): 15-17 |
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| Authors: | Gao Yu-qi Luo Nan-ping Liang Chun et al. |
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| Affiliation: | Gao Yu-qi~1,Luo Nan-ping~2,Liang Chun~(3*),et al. 1 Department of Cardiology,Jinan Military Hospital,Jinan(250031),China 2 Department of Laboratory Medicine,the General Hospital of Jinan Military Region,China 3 Department of Cardiology,Changzheng Hospital,Second Military Medical University,Shanghai(200003),China |
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| Abstract: | Objective To study the possible antiatherogenic mechanism of salvianolate through lowering of serum IL-6 levels in C57BL/6J ApoE~(-/-) mice models of atherosclerosis.Methods ApoE~(-/-) mice models of atherosclerosis were prepared with high fat (chole-sterol) feading for 24 weeks.Beginning from 13 weeks,the models were treated with intraperitoneal injection of salvianolate solution at the dose of 60mg/kg(n = 7 ),120mg/kg(n = 8 ) and 240mg/kg(n = 8 ) daily,5 days per week respectively.Seven models were given ... |
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| Keywords: | salvianolate interleukin-6 ApoE~(-/-) mice radioimmunoassay |
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