检测DM2患者血浆tPA、PAI-1、uPA及uPAR水平的价值

目的:检测2型糖尿病(DM2)血浆tPA、PAI-1、uPA及uPAR水平,探讨其临床价值.方法:分别以ELISA检测尿蛋白正常组、尿蛋白阳性组、严重尿蛋白组和对照组的tPA、PAI-1、uPA及uPAR水平.结果:与对照组相比,尿蛋白正常组的tPA和PAI-1变化不明显(P＞0.05);尿蛋白阳性组tPA活性明显下降...

Clinical Value of Determination of Plasma tPA,PAl-1,uPA and uPAR Levels in Patients with Type 2 Diabetes Mellitus

Objective To study the clinical value of determination of plasma tPA,PAI-1,uPA and uPAR levels in patients with DM2.Methods Plasma tissue plasminogen activator(tPA),tissue plasminogn activator inhibitor-1(PAI-1),urokinase-plasminogen activator(uPA) and urokinase-plasminogen activator receptor(uPAR) levels were determined with ELISA in①32 DM2 patients without albuminuria(uAL<20μg/min)②33 DM2 patients with micro-albuminuria(uAL 20μg/min～200μg/min)③25 DM2 patients with micro-albuminuria(uAL>200μg/min) and④30 controls.Results The plasma levels of tPA and PAI-1 in DM2 patients without albuminuria were not much different from those in controls(P>0.05).The plasma levels of tPA in DM2 patients with micro-albuminuria were significantly lower than those in DM2 patients without albuminuria,again,the levels in patients with macro-albuminuria were significantly lower than those in patients with mciro-albuminuria(both P<0.05).However,the reverse was true for the PAI-1 levels.The plasma uPA and uPAR levels in all the subjects examined were not much different(all P>0.05).Conclusion Determination of plasma tPA and PAI-1 levels in DM2 patients could accurately reflect the degree of nephropathy complicated with.