Cys C、SCr、Hb在肾功能改变中的应用

目的:分析胱抑素C(Cys-C)、血肌酐(SCr)、血红蛋白(Hb)在肾功能变化过程的改变情况.方法:回顾性分析201例行肾动态显像患者,记录同时期患者Cys-C、SCr、Hb的水平,并将两者与肾动态显像计算所得GFB<,总>做相关分析.同时以GFB<,总>为肾功能改变的分级标准,将201例患者分成5组,观察Cys-C...

Changes of Blood Cys C,Creatinine and Hemoglobin Levels in Patients with Different Degrees of Renal Function Impairment

Objective To study the changes of blood cystatin C（Cys C）,creatinine and hemogloblin levels in patients with different levels of GFR.Methods GFR levels were examined with renal dynamic imaging(with ^99mTc-DTPA) in 201 patients with various kinds of chronic renal diseases.Blood Cys C,creatinine and hemoglobin levels were determined with biochemistry in these patients.The patients were divided into 5 groups according to their GFR levels:Group A,GFR≥80min/ml（renal function normal, n = 21）,Group B,60ml/min≤GFR<80ml/min（mild impairment,n = 39）,Group C,30ml/min0.05 ）.Anemia with significant decrease of hemoglobin levels developed in Group D and Group E patients.Blood levels of both Cys C and creatinine were significantly negatively correlated with GFR levels.However,in patients with mild renal function impairment, Cys C was a more sensitive indicator.In this study,among the 39 Group B patients,Cys C levels were increased in 32 cases （82.1%）,but creatinine levels were increased in 14 cases（35.9%） only:the difference was significantly（x²=17.168, P<0.01）.Conclusion Changes of blood Cys C levels could reflect renal function impairment better than changes of blood creatinine level did,especially at the initial stage.Anemia developed later in the course of chronic renal failure.