COPD患者外周血T淋巴细胞亚群的变化及乌体林斯的调节作用

目的:探讨COPD患者外周血T淋巴细胞亚群的变化及乌体林斯治疗COPD的作用机制.方法:100例COPD患者随机分为治疗组和对照组,每组各50例,在我院体检的健康成人50例作为健康体检组.对照组根据病情需要给予抗感染、止咳、祛痰、平喘等综合治疗.治疗组在对照组治疗基础上加用乌体林斯1.72 μg/次,肌肉注射,每周1次...

Regulation of Changes of Peripheral Blood T-lymphocyte Subsets with UtilinsTreatment in COPD Patients

Objective To study the changes of peripheral blood T-lymphocyte subsets after Utilin "s" treatment in COPD patients.Methods Fifty COPD patients were given conventional treatment only and another fifty COPD patients were given additional Utilin "s" treatment.The treatment consisted of Utilin "s" 1.72μg intramuscularly,once oa week for 16 times.The T-lymphocyte subsets in peripheral blood were examined with flow-cytometry both before and after treatment in these 100 patients as well as in 50 controls. Results Before treatment,the CD3~+,CD4~+ T lymphocytes and CD4~+/CD8~+ ratio in the 100 COPD patients were significantly lower than those in the controls(P<0.05 ),while CD8~+ T lymphocytes were significantly higher(P<0.05 ).After sixteen weeks’ treatment,the CD3~+,CD4~+ T lymphocytes and CD4~+/CD8~+ ratio increased significantly in Utilin "s" treatment group,while CD8~+ T lymphocytes decreased significantly(P<0.05).The CD3~+,CD4~+,CD8~+ T lymphocytes and CD4~+/CD8~+ ratio didn’t change significantly in the patients without Utilin "s" treatment(P>0.05).Conclusion There is T-lymphocyte subsets proportion imbalance in COPD patients,and Utilin "s" can regulate such imbalance to some extent.