心房颤动患者血清基质金属蛋白酶-2及其组织抑制因子浓度的变化

目的：研究非瓣膜性心房颤动（NVAf）患者血清基质金属蛋白酶-2（MMP-2）与基质金属蛋白酶组织抑制因子-2（TIMP-2）的水平．探讨NVAf发生的可能机制。方法：采用定量酶联免疫吸附试验（ELISA）测定30例NVAf患者（房颤组）和30例正常人（正常对照组）血清MMP-2、TIMP-2的水平。结果：房颤组血清MMP-2水平（390．29±128．67ng／ml）明显高于正常对照组（291.80±104．15ng／ml）水平（P〈0．01）。房颤组血清TIMP-2水平（62．84±26．77ng／ml）明显低于正常对照组（115．22±45．00ng／ml），P〈0．01，血清MMP-2水平与左房直径呈正相关（r=0．396，P〈0．01）。多因素非条件Logistic回顾模型中左房直径、MMP-2是NVAf发生的危险因素，TIMP-2是保护免于发生房颤的因素。结论：MMP-2与TIMP-2可能参与房颤的发生发展。

Concentrations and significance of plasma matrix metalloproteinase-2 and tissue inhibitor matrix metalloproteinase-2 in atrial fibrillation patients

Objective： To study the plasma levels of matrix metalloproteinase--2 （MMP--2） and tissue inhibitor of matrix metalloproteinase--2 （TIMP--2） in non-valvular atrial fibrillation （NVAf） patients. To investigate the possible mechanism of NVAf. Methods： The plasma levels of MMP--2 and TIMP--2 in 30 NVAf patients （fibrillation group） and 30 sinus rhythm people （control group） were measured by ELISA. Results： The level of MMP--2 in fibrillation group was significantly higher than that in control group [ （390. 29±128. 67） ng/ml ： （291.80±104.15） ng/ml, P %0.01]. The level of TIMP-- 2 in NVAf group was less than that in control group [ （62.84±26.77） ng/ml ： （115.22±45.00） ng/ml, P〈0.01]. The MMP--2 level was positively correlation with left atrial dimension （r= 0. 396, P〈0.01）. The multifaetor Logistic regression analysis show that LAD, MMP--2 were risk factor for N VAf, but the TIMP--2 was protective factor for NVAf. Conclusion： MMP--2 and TIMP--2 may take part in the development of NVAf.