| 卡托普利和氯沙坦对自发性高血压大鼠纤溶功能的影响 |
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| 引用本文： | 郭倩玉,王佩显,杜卫京,肖广辉.卡托普利和氯沙坦对自发性高血压大鼠纤溶功能的影响[J].天津医药,2005,33(1):33-35. |
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| 作者姓名： | 郭倩玉 王佩显 杜卫京 肖广辉 |
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| 作者单位： | 1. 300192,天津市第一中心医院心内科
2. 天津医科大学总医院 |
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| 基金项目： | 天津市自然科学基金资助项目(项目编号:013612011) |
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| 摘 要： | 目的:观察卡托普利和氯沙坦对自发性高血压大鼠(SHR)纤溶酶原激活物抑制剂-1(PAI-1)和组织型纤溶酶原激活物(t-PA)血浆活性及组织表达的影响。方法:SHR分为卡托普利组、氯沙坦组和对照组,用发色底物法测血浆PAI-1和t-PA活性,RT-PCR半定量法测组织表达。结果:SHR主动脉组织PAI-1表达增加,卡托普利(P<0.01)和氯沙坦(P<0.05)使PAI-1表达显著降低。结论:转换酶抑制剂卡托普利和血管紧张素II受体1拮抗剂氯沙坦可减少早期SHR主动脉PAI-1表达,改善局部的纤溶平衡和血管重构。
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| 关 键 词： | 氯沙坦 卡托普利 PAI-1 SHR 自发性高血压大鼠 表达 纤溶功能 结论 目的 平衡 |
Effects of Captopril and Losartan on Fibrinolysis in Spontaneously Hypertensive Rats |
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| GUO Qianyu,WANG Peixian,DU Weijing,XIAO Guanghui.Effects of Captopril and Losartan on Fibrinolysis in Spontaneously Hypertensive Rats[J].Tianjin Medical Journal,2005,33(1):33-35. |
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| Authors: | GUO Qianyu WANG Peixian DU Weijing XIAO Guanghui |
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| Institution: | GUO Qianyu,WANG Peixian,DU Weijing,XIAO Guanghui Department of Cardiology,Tianjin First Central Hospital,Tianjin 300192,China |
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| Abstract: | Objective: To survey the effects of captopril and losartan on plasma plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI-1) activity and their mRNA expressions in aorta in SHR. Methods: SHR were divided into captopril group, losartan group and control group. PAI-1 and t-PA activity in plasma were determined by spectrophotometric assay. The mRNA expressions was determined by semiquantitative RT-PCR. Results: The aorta PAI-1mRNA expression was significantly reduced by captopril(P < 0.01)or losartan(P < 0.05). Conclusion: The fibrinolysis was decreased in aorta tissue in SHR, and the treatment with angiotensin converting enzyme inhibitor(ACEI) or angiotensin II type 1 receptor(AT1) antagonists may improve fibrinolysis in aorta as well as vascular remodeling. |
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| Keywords: | plasminogen activator inhibitor 1 tissue plasminogen activator rats inbred SHR angiotensin-converting enzyme inhibitors |
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