| 布洛芬缓释颗粒的制备及溶出度研究 |
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| 引用本文： | 杜青,张汝华,孙淑英.布洛芬缓释颗粒的制备及溶出度研究[J].中国医药工业杂志,1993(3). |
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| 作者姓名： | 杜青 张汝华 孙淑英 |
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| 作者单位： | 河北医学院 石家庄050017(杜青)，沈阳药学院 辽宁110015(张汝华，孙淑英) |
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| 摘 要： | 使用疏水性材料蜂蜡和硬脂酸制备的布洛芬缓释颗粒,能明显延缓药物释放,体外药物溶出符合零级动力学模型,释药速率与缓释颗粒的粒径有关。扫描电镜照相证明颗粒具有骨架结构。X 射线衍射分析表明,布洛芬在缓释颗粒中仍以结晶形式存在。
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| 关 键 词： | 布洛芬 缓释颗粒 溶出度 |
STUDY ON PREPARATION AND DISSOLUTION OF IBUPROFEN SUSTAINED RELEASE GRANULES |
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| Authors: | DU Qing ZHANG Ru-Huaa SUN Shu-Yinga |
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| Institution: | DU Qing ZHANG Ru-Hua~a SUN Shu-Ying~a |
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| Abstract: | Ibuprofen sustained release granules with the fat-soluble matrixof bee wax and stearic acid were prepared.The dissolution rate of ibuprofenfrom these granules was related to the granule's size and significantly slowerthan the bulk powder,and conformed to zero-order kinetics model.The scanningelectron photomicrograph demonstrated that these granules had matrix structure.X-ray diffraction pattern showed that the crystalline structure of ibuprofen stillexisted in these granules. |
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| Keywords: | ibuprofen sustained release granules dissolution rate |
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