雪上一枝蒿涂膜剂、凝胶剂和巴布剂体外经皮渗透过程的比较

目的:研究雪上一枝蒿涂膜剂、凝胶剂和巴布剂的体外经皮渗透过程,为剂型选择和生产质量控制提供依据。方法:以累积透皮率为指标,运用仿Fick's扩散装置研究雪上一枝蒿涂膜剂、凝胶剂、巴布剂的经皮渗透过程,获得最佳经皮渗透模型,并分析经皮渗透过程与制剂释放过程间的数量关系。结果:3种制剂透皮过程特征不同,其中涂膜剂满足动力学0级过程,而凝胶剂、巴布剂均满足非溶蚀型药物体系释放动力学0级过程,且经皮渗透过程与制剂释放过程间存在良好的三次方程关系。结论:3种制剂的体外经皮渗透模型可作为剂型选择和生产质量控制的依据。

Comparative study on transdermal osmosis in vitro of Aconitum brachypodiumliniment,gel and patcher

Objective: To study the transdermal osmosis process of Aconitum brachypodum's liniment,gel and patcher to provide basis for selecting dosage form and controlling the quality.Method: Taking the cumulate rate of transdermal as index,a imitated Fick's diffusion device was used for the investigating the transdermal osmosis course of the three preparations.The best transdermal mathematics models are obtained and the relations between the transdermal course and the release course are analysed.Result: The three preparations have different characteristics of transdermal osmosis course.The liniment meets dynamics 0 order process,the gel and the patcher meet dynamic 0 order process of non-corroded drug system.And the relation is good cubic equation between their transdermal course and release course.Conclusion: The transdermal osmosis experiment in vitro for three preparations can provide basis for selecting dosage form and the quality control in future studies.