Forensic characteristics and genetic analysis of both 27 Y-STRs and 143 Y-SNPs in Eastern Han Chinese population |
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| Institution: | 1. Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China;2. The Institute of Forensic Science and Technology, Henan Provincial Public Security Bureau, Zhengzhou 450003, China;3. Beijing Police College, Beijing 102202, China;4. Department of Forensic genetics, Brain Hospital of Hunan Province, Hunan University of Chinese Medicine, Changsha 410007, China;5. Criminal Detection Unit of Qingxiu District Public Security Sub-bureau in Nanning, Nanning 530000, China;6. Department of Forensic Science, Zhejiang Police College, Hangzhou 310053, China;7. Forensic Science Institute of Zhejiang Di’an Diagnosis Technology Co., Ltd, Hangzhou 310012, China;8. Forensic Science Center Zhongding Guangdong, Zhanjiang 524000, China;9. Beijing Tongda Shoucheng Institute of Forensic Science, Beijing 100085, China;1. Institute of Forensic Medicine, West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu, China;2. Thermo Fisher Scientific, Shanghai, China;1. Institute of Forensic Medicine, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China;2. School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China;1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Room 109, 2nd Biology Building, Shanghai 200433, PR China;2. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Sciences, Ministry of Justice, PR China, Shanghai 200063, PR China;3. PEOPLESPOTINC R&D, PR China, Beijing 102206, PR China;4. Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, PR China;1. Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, PR China;2. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China;3. Minhang Criminal Police, Shanghai Public Security Bureau, Shanghai 200199, PR China;4. Department of Forensic Medicine, School of Basic Medical Science, Wenzhou Medical University, Wenzhou 325035, PR China;5. Department of Forensic Science, Medical School of Soochow University, Suzhou 215123, PR China;6. College of Medicine and Forensics, Xi’an Jiaotong University Health Science Center, Xi’an, 710061 PR China;1. Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, China;2. Hainan Provincial Blood Center, Haikou 570311, China;1. Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, PR China;2. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China;1. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China;2. Department of Forensic Science, Medical School of Soochow University, Suzhou 215123, PR China;1. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China;2. Department of Forensic Medicine, School of Basic Medical Science, Wenzhou Medical University, Wenzhou, 325035, PR China;1. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China;2. College of Medicine and Forensics, Xi’an Jiaotong University Health Science Center, Xi’an, 710061, PR China;1. Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, PR China;2. Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China |
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| Abstract: | Y-chromosome short tandem repeat (Y-STR) and Y-chromosome single nucleotide polymorphism (Y-SNP) frequency distributions provide resources for assessment of male population stratification among world-wide populations. Currently, the Y-STR Haplotype Reference Database (YHRD) contains numerous Y-chromosome haplotype profiles from various populations and countries around the world. However, for many of the recently discovered and already phylogenetically mapped Y-SNPs, the population data are scarce. Herein, the typing of 27 Y-STRs (Yfiler Plus) and 143 Y-SNPs (self-designed Y-SNP panel) was performed on 1269 unrelated males from 11 Han Chinese populations. Haplogroup O-M175 was the most predominant haplogroup in our Han Chinese data, ranging from 67.34% (Henan Han) to 93.16% (Guangdong Han). The highest haplogroup diversity (0.967056) was observed in Heilongjiang Han, with a discrimination capacity (DC) value of 0.3723. The number of alleles at single-copy loci varied from 2 for DYS391 (Guangdong Han) to 16 for DYS518 (Henan Han). For the majority of the populations (8/11), both the haplotype diversity and DC values are 1.0000. Furthermore, genetic differentiations were observed between Northern and Southern Han Chinese. These genetic differences were mainly reflected in haplogroup distribution and frequency, and they were confirmed by statistical analysis. |
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| Keywords: | Y-chromosome STR Y-chromosome SNP Han Chinese |
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