Development and validation of the EUROFORGEN NAME (North African and Middle Eastern) ancestry panel |
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| Affiliation: | 1. Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Frederik V‘s Vej 11, DK-2100 Copenhagen, Denmark;2. Forensic Genetics Unit, Institute of Forensic Sciences, University of Santiago de Compostela, Spain;3. Faculty of Life Sciences and Medicine, King’s College, London, UK;4. Institute of Forensic Science, Istanbul University, Istanbul, Turkey;5. Department of Legal Medicine, University of Murcia, Murcia, Spain;6. Centre of Biotechnology of Sfax, Bioinformatics Research Group, Sfax, Tunisia;7. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia;8. Department of Anthropology, Faculty of Biology and Environmental Protection, University of Łódź, Poland;1. Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;2. Dipartimento di Biologia e Biotecnologie “L. Spallanzani”, Università di Pavia, Pavia, Italy;3. Faculty of Medical Sciences, Central University of Ecuador, Quito, Ecuador;1. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomic, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, People’s Republic of China;2. Queensland Institute of Medical Research Berghofer Medical Research Institute, Brisbane, Australia;3. Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK;4. Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA;5. Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands;6. Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands;7. Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands;8. Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands;1. Forensic Genetics Unit, Institute of Legal Medicine, University of Santiago de Compostela, Spain;2. Office of the Chief Forensic Scientist, Victoria Police Forensic Services Department, Victoria, Australia;3. University of California San Francisco, San Francisco, California, USA;4. Department of Forensic Science, George Washington University, Mount Vernon College Campus, Washington, USA;5. Department of Biology, University of Aveiro, Aveiro, Portugal;6. Fiji Police Forensic Biology and DNA Laboratory, Nasova, Suva, Fiji;7. Universitat de Barcelona, Barcelona, Spain;8. Galician Foundation of Genomic Medicine (SERGAS), CIBERER (University of Santiago de Compostela), Sanatiago de Compostela, Spain;1. Forensic Genetics Unit, Institute of Forensic Sciences, University of Santiago de Compostela, Spain;2. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia;1. University College Freiburg, Albert-Ludwigs-University Freiburg, Freiburg, Germany;2. Institute of Genetic Epidemiology, Dept. of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany;3. Institute of Biology I, Dept. of Evolutionary Biology and Ecology, Albert-Ludwigs-University Freiburg, Freiburg, Germany |
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| Abstract: | Inference of biogeographic origin is an important factor in clinical, population and forensic genetics. The information provided by AIMs (Ancestry Informative Markers) can allow the differentiation of major continental population groups, and several AIM panels have been developed for this purpose. However, from these major population groups, Eurasia covers a wide area between two continents that is difficult to differentiate genetically. These populations display a gradual genetic cline from West Europe to South Asia in terms of allele frequency distribution. Although differences have been reported between Europe and South Asia, Middle East populations continue to be a target of further investigations due to the lack of genetic variability, therefore hampering their genetic differentiation from neighboring populations. In the present study, a custom-built ancestry panel was developed to analyze North African and Middle Eastern populations, designated the ‘NAME’ panel. The NAME panel contains 111 SNPs that have patterns of allele frequency differentiation that can distinguish individuals originating in North Africa and the Middle East when combined with a previous set of 126 Global AIM-SNPs. |
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| Keywords: | Biogeographic ancestry AIMs SNPs MPS Middle Eastern populations |
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