CDK12 and HER2 coamplification in two urothelial carcinomas with rapid and aggressive clinical progression |
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| Authors: | Yoshinori Yanai Takeo Kosaka Kohei Nakamura Eriko Aimono Kazuhiro Matsumoto Shinya Morita Shuji Mikami Hiroshi Nishihara Mototsugu Oya |
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| Institution: | 1. Department of Urology, Keio University School of Medicine, Tokyo Japan ; 2. Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo Japan ; 3. Department of Diagnostic Pathology, Keio University School of Medicine, Tokyo Japan |
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| Abstract: | Cyclin‐dependent kinase 12 (CDK12), one of the key factors associated with DNA damage response pathways, is located on chromosome 17 proximal to Erb‐B2 receptor tyrosine kinase 2 (ERBB2). In this report, CDK12 and ERBB2 coamplification was detected by targeted next‐generation sequencing in two urothelial carcinomas. The staining intensity of the CDK12 and human epidermal growth factor receptor‐2 proteins was associated with the prognosis of each urothelial carcinoma case. Our results suggest that CDK12 coamplification with ERBB2 might be associated with tumor aggressiveness and contribution to cancer pathogenesis. Therapies targeting CDK12 should be developed for these patients. |
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| Keywords: | CDK12 amplification DNA repair gene ERBB2 prostate cancer urothelial carcinoma |
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