Genetic substructure and forensic characteristics of Chinese Hui populations using 157 Y-SNPs and 27 Y-STRs |
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| Affiliation: | 1. Institute of Forensic Medicine, West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu, China;2. Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, China;3. Institute of Criminal Science and Technology, Karamay City Public Security Bureau, Karamay, China;4. Institute of Criminal Investigation, Zhengzhou City Public Security Bureau, Zhengzhou, China;5. Institute of Criminal Science and Technology Research, Lanzhou City Public Security Bureau, Lanzhou, China;6. Department of Criminal Investigation Bureau of Shaanxi Provincial Public Security, Xi’an, China;7. Institute of Forensic Science, Kunming Public Security Bureau, Kunming, China;1. Laboratorio MANLAB, Área de Filiaciones, Buenos Aires, Argentina;2. Laboratorio de Diversidad Genética, Instituto Multidisciplinario de Biología Celular IMBICE, La Plata, Buenos Aires, Argentina;3. Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina;4. Colegio Oficial de Farmacéuticos y Bioquímicos, Buenos Aires, Argentina;5. Fundación INGEN, Monte Grande, Argentina;6. DNA Diagnostic Laboratory (LDD), State University of Rio de Janeiro (UERJ), Brazil;7. Institute of Pathology and Molecular Immunology from University of Porto (IPATIMUP), Portugal;8. Instituto de Investigação e Inovação em Saúde, I3S, Universidade do Porto, Portugal;9. CMUP, Centro de Matemática da Universidade do Porto, Porto, Portugal;1. Institute for Medical Research, University of Belgrade, Belgrade, Serbia;2. Center for Forensic and Applied Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia;3. Institute of Forensic Medicine, Clinical Center of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia;4. Institute for forensic medicine, criminology and medical deontology, Medical Faculty, University of St. Cyril and Methodius, Skopje, Macedonia;5. Faculty of Mathematics, University of Belgrade, Belgrade, Serbia;6. Institute of History, Belgrade, Serbia;1. Forensic Science SA, GPO Box 2790, Adelaide, South Australia, 5001, Australia;2. College of Science and Engineering, Flinders University of South Australia, GPO Box 2100, Adelaide, South Australia, 5001, Australia;1. Forensic Science SA, GPO Box 2790, Adelaide, South Australia, 5001, Australia;2. College of Science and Engineering, Flinders University of South Australia, GPO Box 2100, Adelaide, South Australia, 5001, Australia;1. Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China;2. Center of Forensic Expertise, Affiliated Hospital of Zunyi Medical University, Zunyi 563099, Guizhou, China;3. School of Forensic Medicine, Zunyi Medical University, Zunyi 563099, Guizhou, China;1. Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China;2. Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, Shanghai 200083, China;3. Laboratory of Infection and Immunity, West China Center of Medical Sciences, Sichuan University, Chengdu 610041, China;4. Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, Shanghai 200063, China;1. Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, China;2. Hainan Provincial Blood Center, Haikou 570311, China |
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| Abstract: | The Hui group is the second largest ethnic minority and one of the most widespread ethnic groups in China. However, the genetic architecture of the Hui population remains largely unexplored, particularly with respect to the male-specific region of the Y chromosome. Here, we studied nine Hui populations (Xinjiang, Qinghai, Gansu, Ningxia, Shaanxi, Henan, Shandong, Sichuan, Yunnan) using 157 Y-chromosome single nucleotide polymorphisms (Y-SNPs) and 27 short tandem repeats (Y-STRs) to unravel their genetic substructure and forensic characteristics. A total of 650 unrelated male samples from the Hui populations were genotyped by SNaPshot®, a single base extension (SBE) assay. Finally, 95 terminal haplogroups and high haplotype diversity (0.9999) were observed in Hui populations. Frequency heat map matrices, genetic distance (FST) and network analysis within Hui populations indicated that these nine Hui populations can be divided into three groups: Hui populations from the northwest (NWH), Hui populations from Sichuan and Shandong (SSH), and Hui populations from Yunnan (YNH). Our results suggested that we should use different databases for different Hui samples in forensic cases. Comparison with other populations that used different population genetic analysis revealed that the Hui populations had close relationships with East Asian populations, especially Chinese Han population. Overall, the high-resolution panel with Y-SNPs and Y-STRs gives new and complete insight into Hui populations, which can be used to interpret the genetic substructure of Hui populations and affect the utility of forensic databases. |
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| Keywords: | Hui populations Y-SNPs Y-STRs Genetic substructure Forensic characteristics |
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