| COPD患者HMGB1与肺功能的相关性分析 |
| |
| 引用本文： | 章俊强,梅晓冬.COPD患者HMGB1与肺功能的相关性分析[J].临床肺科杂志,2011,16(10):1537-1538. |
| |
| 作者姓名： | 章俊强 梅晓冬 |
| |
| 作者单位： | 安徽医科大学附属省立医院呼吸内科,安徽合肥,230001 |
| |
| 摘 要： | 目的研究COPD病人在急性加重期和临床缓解期血中高迁移率族蛋白B1（HMGB1）、肺功能的变化及其相关性分析。方法分别测定COPD病人在急性加重期和经过治疗进入临床缓解期血清HMGB1的浓度及肺功能值（FEV1%、FEV1/FVC）,数据用SPSS 13.0作统计分析。结果急性加重期HMGB1浓度值高于缓解期（P〈0.05）;急性加重期FEV1%低于缓解期（P〈0.05）;加重期和缓解期HMGB1浓度值和FEV1%呈直线负相关（P〈0.05）。结论 1.HMGB1作为炎性分子,在COPD急性加重期血清浓度显著高于缓解期。2.在COPD中HMGB1浓度和肺功能明显相关,提示对于疾病严重程度的判断可能有一定意义。
|
| 关 键 词： | 慢性阻塞性肺疾病 高迁移率族蛋白B1 肺功能 |
Correlative analysis Between HMGB1 and Lung function in patient of chronic obstructive pulmonary clisease |
| |
| ZHANG Jun-qing,MEI Xiao-dong..Correlative analysis Between HMGB1 and Lung function in patient of chronic obstructive pulmonary clisease[J].Journal of Clinical Pulmonary Medicine,2011,16(10):1537-1538. |
| |
| Authors: | ZHANG Jun-qing MEI Xiao-dong |
| |
| Institution: | ZHANG Jun-qing,MEI Xiao-dong.Pulmonary Deapartment,Anhui Provincial Hospital,Hefei 230001,China |
| |
| Abstract: | Objective To investigate the change and correlation between HMGB1 and lung function in acute exacerbation and paracme of COPD.Methods To detect the level of HMGB1 in serum,lung function FEV1%,FEV1/FVC of COPD patient before and after treatment.Result The level of HMGB1 in serum in acute exacerbation is higher than paracme(P<0.05).The level of FEV1% in acute exacerbation is lower than paracme(P<0.05).The negative correlation is occurent between the level of HMGB1 and FEV1%(P<0.05).Conclusion 1.The serum leve... |
| |
| Keywords: | chronic obstructive pulmonary disease HMGB1 lung function |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
