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| Stat3及其靶基因Cyclin D1在喉鳞状细胞癌组织中的表达及临床意义 | |
| 引用本文： | Wang L,Duan X,Tang X,Shao Y,Zhao R,Qian X,Gao X. Stat3及其靶基因Cyclin D1在喉鳞状细胞癌组织中的表达及临床意义[J]. 临床耳鼻咽喉头颈外科杂志, 2011, 25(21): 966-969 |
| 作者姓名： | Wang L Duan X Tang X Shao Y Zhao R Qian X Gao X |
| 作者单位： | 1. 西安交通大学医学院第一附属医院耳鼻咽喉-头颈外科,西安,710061 2. 陕西电子409医院耳鼻咽喉科 3. 南京大学医学院附属鼓楼医院耳鼻咽喉-头颈外科 |
| 摘 要： | 目的:研究喉鳞状细胞癌组织中信号转导和转录激活因子3(Stat3)及其靶基因细胞周期蛋白D1(Cyclin D1)的表达情况并探讨其临床意义。方法:应用Western blot和RT-PCR方法,研究喉鳞状细胞癌组织中Stat3、Cyclin D1蛋白和mRNA的表达情况以及与喉鳞状细胞癌临床病理因素的关系。结果:喉鳞状细胞癌组织中Stat3、Cyclin D1蛋白和mRNA的表达水平明显高于正常喉黏膜组织(P<0.01)。Stat3、Cyclin D1蛋白表达水平与喉鳞状细胞癌临床分期、分化程度及淋巴结转移有关(P<0.01);在喉鳞状细胞癌组织中Stat3蛋白、mRMA与CyclinD蛋白、mRNA的表达均呈正相关(r=0.564、0.552,均P<0.01)。结论:Stat3信号转导通路在喉鳞状细胞癌的发生、发展过程中起重要作用,检测喉鳞状细胞癌组织中Stat3及其靶基因Cyclin D1的表达可以反映肿瘤的恶性程度。 |
| 关 键 词： | 癌 鳞状细胞 信号转导和转录激活因子3 细胞周期蛋白D1 |
Clinical significance of Stat3 and Cyclin D1 expression in laryngeal squamous cell carcinoma |
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| Wang Lingu,Duan Xinhu,Tang Xiabin,Shao Yuan,Zhao Ruimin,Qian Xiaoyun,Gao Xia. Clinical significance of Stat3 and Cyclin D1 expression in laryngeal squamous cell carcinoma[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2011, 25(21): 966-969 | |
| Authors: | Wang Lingu Duan Xinhu Tang Xiabin Shao Yuan Zhao Ruimin Qian Xiaoyun Gao Xia |
| Affiliation: | Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Medical College of Xi' an Jiaotong University, Xi' an710061, China. |
| Abstract: | Objective:To examine the expression and clinical significance of the Stat3 and Cyclin D1 in laryngeal squamous cell carcinoma(LSCC).Method:The expression of Stat3 and Cyclin D1 in LSCC tissue were detected by the RT-PCR and Western blot method respectively,and then the relationship between Stat3 and Cyclin D1 protein expression level and relevant clinical factors of LSCC was explored.Result:Compared to the normal larynx mucosa group,the expression level of Stat3 and Cyclin D1 was significantly higher in LSC... |
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