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| COPD患者营养不良与T淋巴细胞凋亡及其表面Fas、FasL、Bcl-2表达的关系 | |
| 引用本文： | 卓宋明,徐文莉,粱珊瑚,张春艳,叶春幸,余海彬,庄虹,许瑞环. COPD患者营养不良与T淋巴细胞凋亡及其表面Fas、FasL、Bcl-2表达的关系[J]. 临床肺科杂志, 2011, 16(10): 1494-1496 |
| 作者姓名： | 卓宋明 徐文莉 粱珊瑚 张春艳 叶春幸 余海彬 庄虹 许瑞环 |
| 作者单位： | 1. 深圳市龙岗中心医院呼吸内科,广东深圳,518116 2. 深圳市龙岗中心医院中心实验室,广东深圳,518116 3. 深圳市妇幼保健院,广东深圳,518019 |
| 摘 要： | 目的探讨COPD患者营养不良对T淋巴细胞亚群CD4＋、CD8＋T细胞凋亡及其细胞表面Fas、FasL、Bcl-2抗原表达的影响。方法选取COPD稳定期患者30例,正常对照组20例,流式细胞仪测定T淋巴细胞亚群细胞凋亡率、及其表面Fas、FasL、Bcl-2抗原表达水平,测定体质指数、三头肌皮皱厚度等指标评估营养状况。用单因素方差分析进行统计。结果 ：1.COPD患者外周血中CD4＋的凋亡及其表面Fas、FasL抗原表达均较对照组增加,营养不良组又高于营养正常组,而其表面Bcl-2的抗原表达降低。COPD稳定期患者血清CD4＋凋亡及其表面CD4＋Fas、CD4＋FasL的表达均与体质指数负相关,而CD4＋Bcl-2与体质指数则呈正相关。结论营养不良促进COPD患者CD4＋T淋巴细胞的凋亡,可能是通过Fas/FasL,Bcl-2发挥作用。 |
| 关 键 词： | 慢性阻塞性肺疾病 细胞凋亡 营养不良 CD4＋ CD8＋ Fas FasL Bcl-2 |
The Relationship Between The Apoptosis of T Lymphocyte Subsets and the Expression of Fas,FasL,Bcl-2 in Patients with COPD and The effect of malnutrition |
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| ZHUO Song-ming,XU Wen-li,LIANG Shan-hu,ZHANG Chun-yan,YE Chun-xing,YU Hai-bin,ZHUANG Hong,XU Rui-huan. The Relationship Between The Apoptosis of T Lymphocyte Subsets and the Expression of Fas,FasL,Bcl-2 in Patients with COPD and The effect of malnutrition[J]. Journal of Clinical Pulmonary Medicine, 2011, 16(10): 1494-1496 | |
| Authors: | ZHUO Song-ming XU Wen-li LIANG Shan-hu ZHANG Chun-yan YE Chun-xing YU Hai-bin ZHUANG Hong XU Rui-huan |
| Affiliation: | ZHUO Song-ming,XU Wen-li.,LIANG Shan-hu,ZHANG Chun-yan,YE Chun-xing,YU Hai-bin,ZHUANG Hong,XU Rui-huan,Respiratory Department,Department Of Geriatrics,Shenzhen,Guangdong 518116 China |
| Abstract: | Objective To detect the apoptosis of peripheral blood T lymphocyte subsets CD+4,CD+8 T cell and the expression of antigen Fas,FasL,Bcl-2 on their surface in patients with acute exacerbation of COPD,stable COPD and normal,then to discuss the relationship among T Lymphocyte apoptosis,antigen expression and nutritional status.Methods Choose 30 patients with COPD and collected peripheral blood in stable stage,to verify the apoptosis rate of T lymphocyte subsets and the expression of antigen Fas,FasL,Bcl-2 on th... |
| Keywords: | chronic obstructive pulmonary disease apoptosis malnutrition CD 4 CD 8 Fas FasL Bcl-2 |
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