| 不同环境设置对局灶性脑梗死大鼠梗死灶周围神经丝蛋白、胶质纤维酸性蛋白表达的影响 |
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| 引用本文： | 李娜,王天俊,高俊淑,陈景红,贾子善. 不同环境设置对局灶性脑梗死大鼠梗死灶周围神经丝蛋白、胶质纤维酸性蛋白表达的影响[J]. 临床荟萃, 2011, 26(24): 2141-2144 |
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| 作者姓名： | 李娜 王天俊 高俊淑 陈景红 贾子善 |
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| 作者单位： | 1. 河北省人民医院神经内二科,河北石家庄,050051
2. 河北省人民医院康复中心,河北石家庄,050051 |
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| 基金项目： | 河北省科学技术研究与发展计划项目(07276101D-137) |
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| 摘 要： | 目的观察不同环境对局灶性脑梗死大鼠梗死灶周围神经丝蛋白（neurofilament，NF）、胶质纤维酸性蛋白（glialfibrillary acidic protein，GFAP）表达的影响。方法SD大鼠140只。将实验动物随机分为假手术对照组（10只）和大脑中动脉阻断（MCAO）手术组（130只）．再将MCAO手术纽随机分为独居组（30只）、社会交往组（40只）、探索学习组（30只）和丰富环境组（30只）。假手术对照组和各MCAO手术组分别于术后7、28天随机选取5只大鼠处死，采用免疫组织化学染色，观察大鼠梗死灶周围皮质NF、GFAP阳性表达。结果社会交往组、探索学习组和丰富环境组术后7、28天NF、GFAP阳性表达均明显优于独居组和假手术对照组（P〈0．05或〈0．01）。结论社会交往、探索学习和丰富环境均能促进梗死灶周围NF、GFAP的阳性表达。
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| 关 键 词： | 脑梗塞 大鼠 神经微丝蛋白质类 神经胶质原纤维酸性蛋白质 |
Effect of different emvironmental interventions on neurofilament,glial fibrillary acidic protein expression in rats after unilateral local cerebral infarction |
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| LI Na,WANG Tian-jun,GAO Jun-shu,CHEN Jing-hong,JIA Zi-shan. Effect of different emvironmental interventions on neurofilament,glial fibrillary acidic protein expression in rats after unilateral local cerebral infarction[J]. Clinical Focus, 2011, 26(24): 2141-2144 |
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| Authors: | LI Na WANG Tian-jun GAO Jun-shu CHEN Jing-hong JIA Zi-shan |
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| Affiliation: | LI Naa,WANG Tian-juna,GAO Jun-shua,CHEN Jing-honga,JIA Zi-shanb a.Second Department of Neurology,b.Department of Rehabilitation Medicine,Hebei General Hospital,Shijiazhuang 050051,China |
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| Abstract: | Objective To observe effects of different environmental interventions on neurofilament(NF) and glial fibrillary acidic protein(GFAP) expression in rats after unilateral local cerebral infarction.Methods Sprague-Dawley rats were randomly divided into sham operation(n=10) and middle cerebral artery occlusion(MCAO) operation groups.The rats in MCAO group were subjected to electric coagulation of MCA and then were assigned again randomly to individual living group(n=30),social communication group(n=40),learning... |
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| Keywords: | brain infarction rats neurofilament protein glial fibrillary acidic protein |
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