Effects of THA on ionic currents in myelinated axons of Xenopus laevis |
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| Authors: | F Elinder A K Mohammed B Winblad P Arhem |
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| Affiliation: | Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden. |
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| Abstract: | In voltage-clamp experiments with the myelinated nerve fibre of Xenopus laevis, 9-amino-1,2,3,4-tetrahydroacridine (THA) decreased both Na+ and K+ currents and shifted the steady state inactivation potential curve in a negative direction. The effects may be described as (a) a decrease of the permeability constant PNa, (b) a modified potential dependence of the inactivating system and (c) a decrease of PK. The Na+ system was affected more than the K+ system. |
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