Computed tomography detects tissue formation in a stented engineered heart valve |
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| Authors: | de Heer Linda M Budde Ricardo P J Vonken Evert-Jan P A Baaijens Frank P T Gründeman Paul F van Herwerden Lex A Hoerstrup Simon P Kluin Jolanda |
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| Institution: | aDepartment of Cardio-Thoracic Surgery, Division of Heart and Lungs, Utrecht, The Netherlands;bDepartment of Radiology, Imaging Division, University Medical Center Utrecht, Utrecht, The Netherlands;cDepartment of Biomedical Engineering, Cell and Tissue Engineering Laboratory, Eindhoven University of Technology, Eindhoven, The Netherlands;dDivision of Surgical Research and Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland |
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| Abstract: | Tissue-engineered heart valves (TEHV) are being explored as an alternative to conventional heart valve prostheses. Using the classic tissue engineering paradigm, a stented tri-leaflet valve is fabricated. Subsequently, the construct is implanted into the pulmonary position in a sheep. Follow-up by means of computed tomography, magnetic resonance imaging, and echocardiography was used to assess tissue formation. After 4 weeks, the scaffold of the TEHV has degraded and new tissue is formed. However, small areas without tissue formation were present at macroscopic inspection. This phenomenon was only visible on computed tomographic images. Therefore, computed tomography appears a promising technique for in vivo follow-up of tissue formation in tissue-engineered heart valves. |
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| Keywords: | CTSNet classification: 29 |
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