Modification of the DDD Pacing Mode to Prevent Junctional Reentry Tachycardia: Computer Modelling Experiments

This paper examines the possibility of using short atrioventricular (AV) delay dual chamber pacing to prevent junctional reentry tachycardia mediated by an accessory pathway or by an intra-AV nodal circuit. For this purpose, a clinically realistic computer simulation model of cardiac rhythm and heart-pacemaker interactions has been used. The computational experiments compared the actions of two pacemaker models: (A) a clinically realistic DDD mode operating with quasi-Wenckebach prolongation of the AV delay; and (B) a new modification of the DDD mode introducing independent counters for the atrial and ventricular refractory periods of the heart, and the possibility of instantaneous or shortly delayed atrial pacing triggered by a sensed or paced ventricular event. The pathological phenomena modelled in the experiments simulate different possibilities of tachycardia initiation. These disorders include: (1) single atrial premature beats (APBs), (2) salvos of APBs, (3) closely coupled pairs of APBs, (4) ventricular premature beats initiating an antidromic reentry tachycardia, and (5) ventricular ectopic beats initiating an AV nodal reentry tachycardia. The computational results prove that many possible mechanisms of initiation of junctional reentry tachycardia are beyond the prophylactic capabilities of current sophisticated DDD pacemakers (A). The results also show that the suggested pacing mode (B) improves anti-tachycardia prophylaxis even when responding to complex pathological episodes of the natural cardiac activity. Future development of the suggested mode (B) is discussed.