Evidence for alpha 1-adrenoceptor subtype predominance in the rat seminal vesicle |
| |
| Authors: | O O Adenekan |
| |
| Institution: | Department of Pharmacology, Obafemi Awolowo College of Health Sciences, Ogun State University, Sagamu, Nigeria. |
| |
| Abstract: | Noradrenaline (0.6-19 microM) and phenylephrine (2-130 microM) induced contractions in the rat seminal vesicle that were competitively antagonized by the alpha 1-adrenoceptor-selective antagonist corynanthine (120-920 nM). Yohimbine (60-450 nM), an alpha 2-adrenoceptor-selective antagonist, produced a non-competitive antagonism of noradrenaline responses, suggesting that the responses were not alpha 2-adrenoceptor mediated. It is concluded that the rat seminal vesicle has a predominance of alpha 1-adrenoceptors. |
| |
| Keywords: | |
|
|
