| 卵巢癌组织中CA－MoV18抗原的定量放射自显影测定 |
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| 引用本文： | 李培勇.卵巢癌组织中CA－MoV18抗原的定量放射自显影测定[J].中华核医学杂志,1995(3). |
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| 作者姓名： | 李培勇 |
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| 作者单位： | 上海第二医科大学附属瑞金医院核医学科 |
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| 摘 要： | 测定卵巢组织标本中抗原的含量．方法：对３３份卵巢组织标本用放射性碘标记单克隆抗体ＭｏＶ１８进行定量放射自显影测定．其中２２份为卵巢癌，７份为卵巢良性肿瘤，４份为正常卵巢组织．结果：１９份浆液性卵巢癌中，１７份有ＣＡ-ＭｏＶ１８抗原表达，含量为１．３０～５９．２８ｐｍｏｌ／ｇ组织．３份粘液性卵巢癌及１１份非恶性卵巢组织中（７份良性病变，４份正常组织）未测得ＣＡ-ＭｏＶ１８抗原．结论：ＣＡ-ＭｏＶ１８抗原在浆液性卵巢癌中有表达，其含量与肿瘤组织中标记抗体含量（％ＩＤ／ｇ）有关．关键词
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| 关 键 词： | 放射自显影术，抗原，糖蛋白类，卵巢癌 |
QUANTITATIVE AUTORADIOGRAPHY MEASUREMENT OF CA-MoV18 ANTIGEN CONCENTRATION IN OVARIAN CARCINOMAS |
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| Li Peiyong, Del Vecchio S, Lastoria S, et al.QUANTITATIVE AUTORADIOGRAPHY MEASUREMENT OF CA-MoV18 ANTIGEN CONCENTRATION IN OVARIAN CARCINOMAS[J].Chinese Journal of Nuclear Medicine,1995(3). |
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| Authors: | Li Peiyong Del Vecchio S Lastoria S |
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| Abstract: | PURPOSE To measure concentration of CA-MoV18 antigen in ovarian tumor and normal ovarian tissue samples.MEZHODS Quantitative atuoradiography was performed in 33 ovarian tissue samples with radiolabeled MoV18monoclonal antibodies. Among them 22 samples were ovarian carcinomas, 7 samples were benign ovarian tumors and 4samples were normal ovarian tissues. RESULTS Among 19 serous ovarian carcinomas, 17 had MoV18 antigen expression, ranging from 1 .30 to 59.28 pmol / g tissue, 3 mucinous ovarian carcinomas and 11 nonmalignant ovaries (7 benigntumors and 4 normal tissues) were no detectable MoV18 antigen. CONCLUSION CA-MoV18 antigen was expressed in serous ovarian carcinomas. The concentration of CA-MoV18 antigen was correlated with labelled antibodies (%ID / g) in tumor tissue. |
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| Keywords: | Autoradiography Antigens Glycoproteins Ovarian neoplasms |
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