原发性骨非霍奇金淋巴瘤10例

 目的　研究原发骨非霍奇金淋巴瘤（PBL）的临床特征、治疗方法和预后的关系。方法　回顾性分析经病理证实的10例PBL患者的临床资料和治疗效果，Kaplan-Meier法分析患者生存期。结果　10例PBL患者的X线片中均有程度不同的溶骨性破坏；其中B细胞淋巴瘤8例，T细胞淋巴瘤2例；治疗主要采用全身化疗和局部放疗。所有患者治疗后评价完全缓解5例，部分缓解2例，稳定2例，进展1例。中位生存期35.5（4～109）个月，2年生存率66.7 %。结论　PBL以B细胞多见，可侵犯到骨的任何部位，以长骨多见。治疗应以放化疗为主，是一种预后较好的淋巴瘤。

Clinical analysis of primary non-Hodgkin lymphoma of bone:a report of 10 patients

Objective　To investigate the clinical features of primary bone lymphoma (PBL). Methods　Clinical data of 10 patients with pathologically confirmed PBL were analyzed retrospectively, and Kaplan-Meier was used for survival time. Results　X-ray showed osteolysis in all 10 PBL patients. 8 cases were B-cell lymphoma, and 2 were T-cell lymphoma. Local radiotherapy combined with chemotherapy was conducted. The complete remission rate was 50.0%, and the 2-year survival rate was 66.7%. Conclusion　The PBL has been more characterized as diffuse large B-cell lymphoma as of primary non-Hodgkin lymphoma of bone. It can arise in any part of the skeleton, but long bones are the most common sites of presentation. The usual treatments are chemotherapy and local radiotherapy. The prognosis is better and it may be a cured disease.