| 去势雄性SD大鼠胰岛素敏感性的改变 |
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| 引用本文： | 李凡,李小鹰. 去势雄性SD大鼠胰岛素敏感性的改变[J]. 解放军保健医学杂志, 2009, 0(1): 30-32 |
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| 作者姓名： | 李凡 李小鹰 |
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| 作者单位： | 解放军总医院南楼心血管一科; |
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| 基金项目： | 军队面上课题基金(NO.01MA301) |
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| 摘 要： | 目的通过去势手术造成雄性SD大鼠低雄激素状态，并观察其胰岛素敏感性的改变。方法将20只雄性SD大鼠随机分为对照组（n=10）及去势组（n=10）。对去势组进行去势手术。手术8周后，观察各组动物体重改变、血清睾酮（T）、硫化去氢表雄酮（DHEAs）、空腹血糖（FBG）、空腹胰岛素（Fins）水平；并在第8周时进行高胰岛素正葡萄糖钳夹试验，以评价大鼠胰岛素敏感性。结果去势组大鼠T水平明显下降（5．94±1．13降至0．11±0．02nmol·L^-1，P〈0．01），DHEAs水平明显下降（12．49±3．17降至9．19±2．87ng·ml^-1，P〈0．05），血清Fins水平（0．92±0．38ng·dl^-1）高于对照组（0．34±0．14ng·dl^-1）（P〈0．01），葡萄糖清除率（GDR）（6．45±2．86mg·kg^-1·min^-1）低于对照组（16．21±4．73mg·kg^-1·min^-1）．（P〈0．01），FBG无明显差异。结论雄性SD大鼠去势后，体内T、DHEAs降低，Fins升高，胰岛素敏感性明显下降。
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| 关 键 词： | 胰岛素抵抗 血清睾酮 硫化去氢表雄酮 去势大鼠 |
The change of insulin sensitivity in castrated male SD rats |
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| LI Fan,LI Xiaoying. The change of insulin sensitivity in castrated male SD rats[J]. Journal Of Health Care And Medicine in Chinese Pla, 2009, 0(1): 30-32 |
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| Authors: | LI Fan LI Xiaoying |
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| Affiliation: | The First Department of Cardiology of South Building;PLA General Hospital;Beijing 100853;China |
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| Abstract: | Objective This study was designed to examine the change of insulin sensitivity in castrated male rats.Methods 20 male SD rats were randomly assigned into two groups:control group,normal rats(n=10);castrated group,castrated rats(n=10).8 weeks later,animals' blood samples were taken to assess the level of hormone,fasting blood glucose and fasting insulin.Insulin sensi-tivity was followed by euglycaemic,hyperinsulinaemic glucose clamp measurements.Results(1)Castrated rats' serum T and DHEAs concentrations decl... |
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| Keywords: | Insulin resistance T DHEAs Castrated rat |
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