甲状腺乳头状癌组织中miR-182表达情况及其与临床病理特征的关系

Objective: To investigate the expression of miR-182 in papillary thyroid carcinoma and its relationship with clinicopathological features. Methods: Ninety-eight cases of papillary thyroid carcinoma tissues confirmed by pathology (study group) and their corresponding para-cancerous tissues (control group) were collected, and quantitative polymerase chain reaction (qPCR) was used to determine the level of miR-182 in thyroid papillary carcinoma tissues and paracancerous tissues. The relationship of patients' clinicopathological characteristics and prognosis was analyzed. Results: The expression of miR-182 in the study group was higher than that in the control group [(1.89±0.48) vs (0.66±0.21), P<0.01]. The expression of miR-182 was positively correlated with pathological grade, TMN stage, depth of invasion, lymphatic vascular infiltration, and lymph node metastasis (all P<0.01). In the study group, taking the mean miR-182 level of 1.89 as the decision point, the 3-year survival rate of the miR-182 positive (≥1.89) group was significantly lower than that of the miR-182 negative (<1.89) group (27.9% vs 80.0%, P<0.01). Conclusions: The expression of miR-182 is elevated in papillary thyroid carcinoma, and miR-182 may play a role in promoting the development of papillary thyroid carcinoma. Patients with low expression of miR-182 may have better prognosis. © 2021, The Second Affiliated Hospital, College of Medicine, Zhejiang University.. All right reserved.

Expression of miR-182 in papillary thyroid carcinoma and its relationship with clinicopathological features