The new drug combinations: their place in the treatment of uncomplicated Plasmodium falciparum malaria |
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Authors: | Danis Martin Bricaire François |
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Affiliation: | Service de Parasitologie-Mycologie and Unité INSERM 511, Centre Hospitalier Universitaire Pitié-Salpêtrière, Assistance Publique-H?pitaux de Paris, Université Paris 6, 47 bd de l'H?pital, 75651 Paris cedex 13, France. |
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Abstract: | Malaria is a leading cause of morbidity and mortality in developing countries. Selection of mutant Plasmodium falciparum malaria strains under drug pressure has led to the development of drug resistance. There is a pressing need for effective, safe, practicable drug combinations that hve lower selection pressure. A review of the mein drug combinations, which are recently registered or are still under development, was undertaken, with special attention to the atovaquone-proguanil and artemether-lumefantrine combination. |
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Keywords: | antimalarial drug combinations chemoresistance falciparum malaria |
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