血管紧张素转换酶基因多态性与原发性高血压的关系

目的：探讨辽宁地区汉族原发性高血压病人与血管紧张转换酶（ＡＧＥ）基因多态性的关系。方法：应用聚合酶链反应检测６９例原发性高血压（ＥＨ）病人及９９例健康汉族人的ＡＣＥ基因多态性的分布情况。结果：ＥＨ组的基因型分别为：纯合插入型（ＩＩ）２１．７％、纯合缺失型（ＤＤ）３４．８％、杂合型（ＩＤ）４３．５％；正常对照 分别为：３９．４％、１４．１％、４６．９％。前者Ｄ等位基因频率（０．５６５）明显高于对照组

Association Between Angiotensin I Converting Enzyme Gene Polymorphism and Essential Hypertension

Objective: Our purpose was to investigate the association between essential hypertension (EH) among people of Han nationality in Liao Ning province and angiotensin I converting enzyme (ACE) gene polymorphism. Methods: The insertion/deletion (I/D) polymorphism of ACE gene was detected by polymerase chain reaction in 69 EH patients and 99 normotensive subjects. Results: Genetypes were homozygous inserting (II, 21.7%), homozygous deletion (DD, 34.8%), and heterozygous (ID, 43.5%), in EH patients. Their expression in normal control were 39.4%, 14.1%,and 46.9%. The frequency of the ACE D allele was higher in the EH group (0.565) than that in normal control group (0.374). The frequency of the ACE allele was higher in the female EH patients (0.625) than that in the healthy women (0.321). At the same time, clinical symptoms of the patients with the D allele were severe, and unfavourable prognosis of the patients was found. Conclusion: These findings suggest that a deletion polymorphism is associated with EH and sexuality in China.