雌激素对脑缺血再灌注时SOD和MDA的影响

目的：通过观察雌激素对脑缺血再灌注时超氧化物歧化酶(SOD)、丙二醛(MDA)的影响．探讨雌激素在脑缺血再灌注中的神经保护作用。方法：取沙土鼠48只．随机分为假手术组(A组)、单纯脑缺血再灌注组(B组)、卵巢切除的脑缺血再灌注组(C组)、卵巢切除后给予苯甲酸雌二醇治疗的脑缺血再灌注组(D组)．采用双侧颈总动脉夹闭法复制沙土鼠脑缺血再灌注模型．于术后12h处死动物取材，测定SOD活性和MDA含量。结果：B组和D组SOD活性高于C组；MDA含量低于C组。结论：雌激素可以减少脑缺血再灌注时自由基的产生．从而提供神经保护作用。

Effects of Estrogen on SOD Activity and MDA Contents in Cerebral Ischemia Reperfusion

Objective:To investigate the neuroprotective role of estrogen by observing the effects of estrogen on SOD activity and MDA contents in cerebral ischemia reperfusion. Methods: 48 adult famale pallasiomies were randomly divided into four groups: normal group(A), intact group(B), ovariectomixed group(C) and E2 treated ovariectomixed group(D). The pallasiomies'cerebral ischemia reperfusion models were made by the bilateral occlusion of common carotid arteries. 12 h after operation, the pallasiomies were decapitated and the brain tissues were sampled to measure SOD activity and MDA contents. Results: Compared with the C group, SOD activities were markedly increased and MDA contents were reduced in the B and D groups. Conclusion: Estrogen can decrease the production of oxygen free radicals in cerebral ischemia reperfusion, which may be an important mechanism in estrogen mediated neuroprotection.