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Herpes simplex encephalitis: an autopsy case with isolation of type 1 herpes simplex virus |
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| Authors: | Shozo Miyake Shigeru Yasuraoka Yasuyoshi Kiryu Eijiro Satoyoshi Takeshi Kurata Yuzo Aoyama |
| Institution: | (1) Department of Internal Medicine, Nippon Kokan Hospital, Kawasaki, Japan;(2) Department of Internal Medicine, Toho University, School of Medicine, Tokyo, Japan;(3) Department of Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan |
| Abstract: | Summary An adult case of herpes simplex encephalitis was studied after autopsy. Postmortem examination revealed necrotizing encephalitis associated with Cowdry type A intranuclear inclusion bodies in glial cells. Herper simplex virus type 1 was isolated from the removed brain. Herpes simplex virus antigens were detected diffusely in wide areas of the brain by immunofluorescent test and viral particles characteristic to herpes simplex virus were demonstrated by electron microscopy. There was an apparent discrepancy between severity of histological changes and distribution of virus antigen. |
| Keywords: | Herpes simplex virus Herpes simplex encephalitis Herpes simplex virus type 1 |
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