| Survivin和PTEN基因在原发性肝细胞癌中的表达及意义 |
| |
| 引用本文： | 张玉萍,朱金玲,侯霞,张淑红,张虎,王长山. Survivin和PTEN基因在原发性肝细胞癌中的表达及意义[J]. 中国优生与遗传杂志, 2011, 0(5): 17-19 |
| |
| 作者姓名： | 张玉萍 朱金玲 侯霞 张淑红 张虎 王长山 |
| |
| 作者单位： | 佳木斯大学基础医学院; |
| |
| 基金项目： | 黑龙江省教育厅科学技术研究项目,No11541371 |
| |
| 摘 要： | 目的探讨凋亡抑制基因Survivin和抑癌基因PTEN在原发性肝细胞癌及癌旁组织中的表达及其相关性。方法应用RT-PCR法,对50例原发性肝细胞癌和34例癌旁组织中Survivin和PTEN基因的表达情况进行定量检测。结果 Survivin在原发性肝细胞癌组织中高表达,而在癌旁组织中无表达;原发性肝细胞癌中PTEN的表达量明显低于癌旁组织;Survivin和PTEN的表达量与原发性肝细胞癌的分化程度有关,与患者发病年龄、肿瘤大小、门静脉癌栓、肝内转移无关;随着恶性程度加重,Survivin和PTEN基因表达呈显著负相关。结论 Survivin和PTEN在原发性肝细胞癌发生、发展中起着不同的作用,联合检测对原发性肝细胞癌的早期诊断、判定预后提供一定的临床依据。
|
| 关 键 词： | 原发性肝细胞癌 Survivin PTEN RT-PCR |
Expression and significance of survivin and PTEN gene in primary hepatocellular carcinoma. |
| |
| ZHANG Yu-ping,ZHU Jin-ling,HOUI Xia,ZHANG Shu-hong,ZHANG Hu,WANG Chang-shan.. Expression and significance of survivin and PTEN gene in primary hepatocellular carcinoma.[J]. Chinese Journal of Birth Health & Heredity, 2011, 0(5): 17-19 |
| |
| Authors: | ZHANG Yu-ping ZHU Jin-ling HOUI Xia ZHANG Shu-hong ZHANG Hu WANG Chang-shan. |
| |
| Affiliation: | ZHANG Yu-ping,ZHU Jin-ling,HOUI Xia,ZHANG Shu-hong,ZHANG Hu,WANG Chang-shan.(The Basic Medical College,Jiamusi University,Jiamusi 154007,Heilongjiang Province,China) |
| |
| Abstract: | Objective:To investigate the expression of Survivin and PTEN gene and their relationship in primary hepatocellular carcinoma and adjacent tissues.Methods:The expression of Survivin and PTEN were determined in 50 cases of hepatocellular carcinoma and 34 cases of corresponding noncancerous tissues by RT-PCR,and the quantitative detection were followed.Results:Survivin in primary hepatocellular carcinoma is highly expressed in cancer tissues and no expression in corresponding noncancerous tissues;the expressio... |
| |
| Keywords: | Primary hepatocellular carcinoma Survivin PTEN RT-PCR |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
