合并胎儿生长受限是否预示早发型重度子痫前期疾病加重

目的探讨胎儿生长受限的发生是否预示早发型重度子痫前期疾病的加重,以期为临床处理提供依据。方法回顾分析了1998年1月至2008年12月北医三院产科收治的早发型重度子痫前期患者166例,其中合并胎儿生长受限58例,未合并的108例。比较两组一般情况,病情严重程度及孕产妇并发症的差异。结果早发型重度子痫前期患者中胎儿生长受限的发生率为34.9%。两组患者一般情况包括发病年龄、初产妇构成比、规律产检率以及既往妊娠期高血压疾病史发面均无统计学差异(P>0.05)。胎儿生长受限组最高收缩压、舒张压,以及最大尿蛋白定量均稍低于对照组,但是无明显统计学差异。而胎儿生长受限组血压控制在小于140/90mmHg的患者明显多于非FGR组,并且FGR组仅口服单种降压药的患者较非FGR组多。产前超声检查中FGR组羊水指数明显小于非FGR组,而脐血流S/D比值明显升高。两组患者并发症包括子痫、HELLP综合征、胎盘早剥、心衰、脑水肿的发生均无显著差异。结论早发型重度子痫前期合并FGR并不预示子痫前期疾病加重。但提示胎儿宫内生长环境较恶劣。

If fetal growth restriction happened in severe early-onset preeclampsia is a measure of severity of disease

Objective: To discuss the question if fetal growth restriction happened in severe early-onset preeclampsia is a measure of severity of disease.Methods: Retrospective analysis of the severe early-onset preeclampsia patients from the years 1998 to 2008 in our hospital.A total number of 166 cases were collected,excluding the patients with primary hypertension,chronic nephritis and multiple pregnancies.Fetal growth restriction(FGR) co-existed in 58 patients.We discuss the difference of these two groups about th...