| 紫草素对人鼠嵌合内异位症模型血管内皮生长因子表达的影响 |
| |
| 引用本文： | 倪婕,顾林,史颖莉,陈捷,石晓燕,朱烨.紫草素对人鼠嵌合内异位症模型血管内皮生长因子表达的影响[J].中国优生与遗传杂志,2011(1):56-57,2,F0002. |
| |
| 作者姓名： | 倪婕 顾林 史颖莉 陈捷 石晓燕 朱烨 |
| |
| 作者单位： | 南京医科大学附属南京妇幼保健院; |
| |
| 基金项目： | 江苏省自然科学基金(BK2006577); 南京市医学重点科技发展项目(ZKX08004); 南京医科大学科技发展基金重点项目(07NMU2022)资助 |
| |
| 摘 要： | 目的通过研究紫草素对内异症小鼠模型血管内皮生长因子（VEGF）表达的影响,探究其治疗子宫内膜异位症（EMs）的可能机制。方法建立人鼠嵌合内异症动物模型,随机分为紫草素大、中、小剂量组,另设PBS阴性对照组及达菲林阳性对照组,采用免疫组化法,比较用药前后移植人子宫内膜VEGF表达变化情况。结果各剂量紫草素均抑制VEGF表达,大、中剂量组与阴性对照组相比差异有统计学意义（P〈0.05）,与达菲林组比较无显著性差异（P〉0.05）。结论紫草素可能通过抑制异位内膜血管新生,阻止其种植和生长而治疗EMs。
|
| 关 键 词： | 紫草素 子宫内膜异位症 VEGF 免疫组化 |
Expression of vascular endothelial growth factor in SCID endometriosis models affected by shikonin |
| |
| NI Jie,GU Lin,SHI Ying-li,CHEN Jie,SHI Xiao-yan,ZHU Ye..Expression of vascular endothelial growth factor in SCID endometriosis models affected by shikonin[J].Chinese Journal of Birth Health & Heredity,2011(1):56-57,2,F0002. |
| |
| Authors: | NI Jie GU Lin SHI Ying-li CHEN Jie SHI Xiao-yan ZHU Ye |
| |
| Institution: | NI Jie,GU Lin,SHI Ying-li,CHEN Jie,SHI Xiao-yan,ZHU Ye.(Nanjing Maternity and Child Health Hospital,Nanjing Medical University,Nanjing,210004) |
| |
| Abstract: | Objective: To study the effect of shikonin on expression of vascular endothelial growth factor in SCID endometriosis models,thus exploring the potential mechanism of shikonin on therapy of endometriosis.Methods: SCID endometriosis models were established and randomly divided into five groups: high-dose shikonin group,middle-dose shikonin group,low-dose shikonin group,PBS negative control group and Diphereline-treated positive control group.The VEGF in human endometrium transplanted into SCID mice was measur... |
| |
| Keywords: | Shikonin Endometriosis VEGF Immunohistochemisty |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
