MMP-2、MMP-9及EMMPRIN在子宫内膜异位症中的表达及临床意义

目的研究基质金属蛋白酶2（MMP-2）、基质金属蛋白酶9（MMP-9）、细胞外基质金属蛋白酶诱导因子（EMMPRIN）在子宫内膜异位症（EMs）的表达和意义。方法应用免疫组化二步法检测EMs患者异位内膜42例、在位内膜42例及正常内膜20例中的MMP-2、MMP-9、EMMPRIN的表达情况,并对它们的EMMPRIN、MMP-2、MMP-9蛋白表达水平进行相关性分析。结果 MMP-2、MMP-9、EMMPRIN在异位内膜组中阳性表达率分别为95.24%、92.86%和90.48%,显著高于在位内膜组、正常内膜组（P〈0.05）;而在位内膜组和正常内膜组差异无统计学意义（P〉0.05）。异位内膜组中,EMMPRIN分别和MMP-2,MMP-9呈正相关性（P〈0.01）。结论 MMP-2、MMP-9、EMMPRIN共同参与了子宫内膜异位症的发生发展;EMMPRIN可能通过促进MMP-2和MMP-9的合成与分泌发挥其作用。

Expression and significance of MMP-2,MMP-9 and VEGF in endometriosis

Objective： To investigate the expression and significance of EMMPRIN, MMP- 2 and MMP- 9 in endometriosis （EMs）. Methods： The expression of MMP-2, MMP-9 and EMMPRIN in 42 eases of eetopie endometrium, 42 eases of eutopie endometrial and 20 eases of normal endometrium were detected by two - step immunohistoehemical method, then the correlation of the expression of them was evaluated. Results ： The MMP - 2, MMP - 9 and EMMPRIN positive expression rate was 95.24% , 92. 86% and 90. 48% respectively in the eetopie endometrium group, which were significantly higher than their counterparts in the eutopie endometrial group and the normal endometrium group （ P 〈 0.05 ） ; there was not significant difference between the eutopie endometrial group and the normal endometrium group. The expression of EMMPRIN protein was positively correlated with MMP - 2, 9 in the eetopie endometrium group （P 〈 0. 01 ）. Conclusion： EMMPRIN, MMP- 2 and MMP- 9 are all involved in the process of invasionand tissue remodeling, which is supposed to be part of pathogenesis of endometriosis and EMMPRIN protein plays its role probably through activa- ting MMP- 2, 9 synthesis and secretion.