| STAT3在宫颈鳞状上皮病变组织中的表达及意义 |
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| 引用本文： | 陈英,范怡冰. STAT3在宫颈鳞状上皮病变组织中的表达及意义[J]. 中国优生与遗传杂志, 2011, 0(1): 29-30,18 |
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| 作者姓名： | 陈英 范怡冰 |
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| 作者单位： | 扬州大学第五临床医学院;常熟市第二人民医院妇产科; |
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| 摘 要： |
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| 关 键 词： | 信号转录和转录活化因子3 宫颈上皮内瘤变 宫颈鳞状上皮细胞癌 |
STAT3 expression in cervical squamous intraepithelial lesions and its significance |
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| CHEN Ying,FAN Yi-bing.. STAT3 expression in cervical squamous intraepithelial lesions and its significance[J]. Chinese Journal of Birth Health & Heredity, 2011, 0(1): 29-30,18 |
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| Authors: | CHEN Ying FAN Yi-bing. |
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| Affiliation: | CHEN Ying,FAN Yi-bing.(Department of Gynecology and Obstetrics,the 2nd Hospital of ChangShu,ChangShu City JiangShu Province,China,215500) |
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| Abstract: | Objective： This study aimed at investigating STAT3 expression in cervical squamous intraepithelial lesions and their significance.Methods： By means of semi-quantitive RT-PCR,we haved evaluated STAT3 expression at mRNA levels in 13 cases cervicitis tissues,12 cervical intraepithelial neoplasia （CIN） Ⅰ、17 CINⅡ-Ⅲand 33 squamous cell carcinoma （SCC） tissues.Results： STAT3 expression showed no correlation with the grade of cervical intraepithelial lesions and clinical stage （P〉 0.10 respectively） ,positively correlated with pathological grade （r = 0.52,P 〈0.05） ,the group of vascular invasion and lymph node metastasis and depth of invasion 3mm were higher than those contrast lesion group （P 〈0.05 respectively）.Cox regression analysis showed that STAT3 expression has no relationship with poor prognosis of SCC.Conclusions： STAT3 can not directly contribute to the incidence and development of SCC,but plays a direct role in promoting SCC invasion,metastasis,differentiation.Anti-cancer therapeutic strategies targeting STAT3 for cervical cancer remains to be studied further. |
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