| 甘肃部分地区373例男性不育患者Y染色体AZF微缺失基因诊断的研究 |
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| 引用本文： | 郝胜菊,冯暄,闫有圣.甘肃部分地区373例男性不育患者Y染色体AZF微缺失基因诊断的研究[J].中国优生与遗传杂志,2011(10):43-45,91. |
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| 作者姓名： | 郝胜菊 冯暄 闫有圣 |
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| 作者单位： | 甘肃省妇幼保健院; |
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| 摘 要： | 目的研究甘肃地区男性不育患者Y染色体AZF区域微缺失的频率、分布情况方法采用多重PCR技术,对甘肃地区373例男性不育症患者进行Y染色体AZFa,AZFb,AZFc三个区域6个STS位点的微缺失检测。结果 373例男性不育患者中,42例发生了STS位点缺失,缺失率11.3%。其中无精子症因子AZFa(SY86,SY84)区未见缺失;AZFb(SY127,SY134)区缺失4例(9.52%);AZFc(SY254,SY255)区缺失32例(76.2%);AZFb+c区缺失5例(11.9%);AZFa+b+c缺失1例(2.38%)。结论甘肃部分地区AZF区域微缺失的频率、分布与国内其他报道一致,但是在本研究中未检测到AZFa区缺失患者。
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| 关 键 词： | 男性不育 无精子症 Y染色体微缺失 无精子症因子 |
The study of gene diagnosis for Y chromosome microdeletion in 373 male patients with infertility in Gansu province |
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| HAO Sheng-ju,et al..The study of gene diagnosis for Y chromosome microdeletion in 373 male patients with infertility in Gansu province[J].Chinese Journal of Birth Health & Heredity,2011(10):43-45,91. |
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| Authors: | HAO Sheng-ju |
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| Institution: | HAO Sheng-ju,et al.(Gansu Maternal Child Health Care Hospital,Gansu,Lanzhou) |
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| Abstract: | Objective: To investigate the frequency and distribution of Y chromosome microdeletion in male patients with infertility in Gansu province.Methods: Multiplex PCR was preformed within the Azoospermia factor(AZF) region to detect Y chromosome microdeletion in 373 infertile male patients.Results: In 373 infertile male patients,42(11.3%) were found to have Y chromosome microdeletion in AZF regions.Among the 42 cases,none deletion was in AZFa,4(5.93%) deletions were in AZFb,32(76.2%) deletions were in AZFc and 5... |
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| Keywords: | Male infertility Azoospermia Y chromosome microdeletion Azoospermia factor |
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