| Y染色体微缺失及生殖激素水平改变与少精子、无精子症关系的研究 |
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| 引用本文： | 田艳,王厚照,马芳芳,许博.Y染色体微缺失及生殖激素水平改变与少精子、无精子症关系的研究[J].中国优生与遗传杂志,2011(8):15-16,44. |
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| 作者姓名： | 田艳 王厚照 马芳芳 许博 |
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| 作者单位： | 解放军第174医院检验科; |
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| 摘 要： | 目的探讨Y染色体微缺失及生殖激素水平改变与少精子、无精子症间的关系。方法应用多重聚合酶链反应技术对256例少精子、无精子患者（少精子症92例,无精子症164例）和正常对照组50例进行Y染色体微缺失检测以及生殖激素水平检测。结果发现256例少精子、无精子症患者中无精子因子（azoospermia factor,AZF）微缺失的发生率为12.89%（33/256）,其中164例无精子症患者微缺失24例（24/164,14.63%）,92例少精子症患者微缺失9例（9/92,9.78%）;少精子、无精子症病人中卵泡刺激素（FSH）、黄体生成素（LH）的量明显高于正常对照组（P〈0.05或P〈0.01）;而睾酮（T）的含量明显低于对照组（P〈0.05或P〈0.01）;血清泌乳素（PRL）和雌二醇（E2）的含量与正常组相比差异无明显性（P〉0.05）。结论 Y染色体微缺失及FSH、LH、T水平与少精子、无精子症关系密切,可能是引起少精子、无精子症的原因之一。
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| 关 键 词： | Y染色体 染色体缺失 少精子症 无精子症 |
The clinical significance of azoospermia factor(AZF) region deletion and reproductive hormone in semen of patients with idiopathic azoospermia and oligospermia |
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| TIAN Yan,WANG Hou-zhao,MA Fang-fang,XU Bo.The clinical significance of azoospermia factor(AZF) region deletion and reproductive hormone in semen of patients with idiopathic azoospermia and oligospermia[J].Chinese Journal of Birth Health & Heredity,2011(8):15-16,44. |
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| Authors: | TIAN Yan WANG Hou-zhao MA Fang-fang XU Bo |
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| Institution: | TIAN Yan,WANG Hou-zhao,MA Fang-fang,XU Bo(174th Hospital of PLA,Xiamen,Fujian 361003,China) |
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| Abstract: | Objective:To explore the clinical significance of azoospermia factor(AZF) region deletion and reproductive hormone in semen of patients with idiopathic azoospermia and oligospermia,then further analyze the relationship between them.Methods:Detection of reproductive hormone the Y-link sequence tagged sites in AZF region was conducted by means of polymerase chain reactions among 92 patients with severe oligozoospermia and 164 patients with azoospermia,totally 256.Results:33 cases of microdeletion were found a... |
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| Keywords: | Y chromosome Chromosome deletion Azoospermia and oligospermia |
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