| TRB3 Q84R基因多态性与不同表型多囊卵巢综合征的相关性 |
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| 引用本文： | 张雪,傅莉,张秋芳,闫丽盈,马延敏,涂彬彬,刘娜娜,乔杰. TRB3 Q84R基因多态性与不同表型多囊卵巢综合征的相关性[J]. 中国优生与遗传杂志, 2011, 0(5): 23-24 |
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| 作者姓名： | 张雪 傅莉 张秋芳 闫丽盈 马延敏 涂彬彬 刘娜娜 乔杰 |
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| 作者单位： | 北京大学第三医院妇产科;首都医科大学附属北京妇产医院; |
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| 摘 要： | 目的探讨TRB3 Q84R基因多态性与不同表型多囊卵巢综合征（Ⅰ型：O＋H＋P;Ⅱ型：O＋H;Ⅲ型：H＋P;Ⅳ型：O＋P）的相关性。方法采用聚合酶链反应-限制性片段长度多态性（polymerase chain reaction-restriction frag-ment length polymorphism,PCR-RFLP）方法检测TRB3 Q84R的基因多态性。结果 TRB3 Q84R基因型频率分布在Ⅰ型P-COS组（O＋H＋P）与对照组之间有显著性差异（P〈0.05）;其余PCOS表型与对照组之间基因型频率分布无显著性差异（P〉0.05）。结论 TRB3 Q84R基因多态性与Ⅰ型PCOS相关。
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| 关 键 词： | TRB3 胰岛素抵抗 多囊卵巢综合征 多态性 |
Relationship of TRB3 Q84R polymorphism with different phenotypes of polycystic ovary syndrome |
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| ZHANG Xue,FU Li,ZHANG Qiu-fang,YAN Li-ying,MA Yan-min,TU Bin-bin,LIU Na-na,QIAO Jie.. Relationship of TRB3 Q84R polymorphism with different phenotypes of polycystic ovary syndrome[J]. Chinese Journal of Birth Health & Heredity, 2011, 0(5): 23-24 |
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| Authors: | ZHANG Xue FU Li ZHANG Qiu-fang YAN Li-ying MA Yan-min TU Bin-bin LIU Na-na QIAO Jie. |
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| Affiliation: | ZHANG Xue1,FU Li1,ZHANG Qiu-fang1,YAN Li-ying1,MA Yan-min2,TU Bin-bin1,LIU Na-na1,QIAO Jie1.(1.Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China,2.Reproductive Medical Center,Beijing Obstetrics and Gynecology Hospital Affiliated of Capital Medical University,Beijing 100026,China) |
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| Abstract: | Objective: To investigate whether TRB3 Q84R polymorphism was associated with different phenotypes of polycystic ovary syndrome(type I : O+H+P;type II : O+H;type III : H+P;type IV : O+P).Methods: The TRB3 Q84R polymorphisms were analysed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results: The genotype distributions were significantly different between type I of PCOS and control group(P<0.05) while the genotype frequencies were not significantly different between the other... |
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| Keywords: | TRB3 Insulin resistance Polycystic ovary syndrome(PCOS) Polymorphism |
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